Title:
PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE
Document Type and Number:
WIPO Patent Application WO2004104001
Kind Code:
A3
Abstract:
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
Inventors:
BRADLEY STUART EDWARD (GB)
KRULLE THOMAS MARTIN (GB)
MURRAY PETER JOHN (GB)
PROCTER MARTIN JAMES (GB)
ROWLEY ROBERT JOHN (GB)
SAMBROOK SMITH COLIN PETER (GB)
THOMAS GERARD HUGH (GB)
SCHOFIELD KAREN LESLEY (GB)
KRULLE THOMAS MARTIN (GB)
MURRAY PETER JOHN (GB)
PROCTER MARTIN JAMES (GB)
ROWLEY ROBERT JOHN (GB)
SAMBROOK SMITH COLIN PETER (GB)
THOMAS GERARD HUGH (GB)
SCHOFIELD KAREN LESLEY (GB)
Application Number:
PCT/US2004/016243
Publication Date:
March 03, 2005
Filing Date:
May 20, 2004
Export Citation:
Assignee:
OSI PHARM INC (US)
BRADLEY STUART EDWARD (GB)
KRULLE THOMAS MARTIN (GB)
MURRAY PETER JOHN (GB)
PROCTER MARTIN JAMES (GB)
ROWLEY ROBERT JOHN (GB)
SAMBROOK SMITH COLIN PETER (GB)
THOMAS GERARD HUGH (GB)
SCHOFIELD KAREN LESLEY (GB)
BRADLEY STUART EDWARD (GB)
KRULLE THOMAS MARTIN (GB)
MURRAY PETER JOHN (GB)
PROCTER MARTIN JAMES (GB)
ROWLEY ROBERT JOHN (GB)
SAMBROOK SMITH COLIN PETER (GB)
THOMAS GERARD HUGH (GB)
SCHOFIELD KAREN LESLEY (GB)
International Classes:
A61P9/10; C07D471/04; C07D519/00; (IPC1-7): C07D471/00; C07D519/00; A61K31/437; A61P9/10
Domestic Patent References:
| WO2002020530A1 | 2002-03-14 | |||
| WO2000044753A1 | 2000-08-03 | |||
| WO2003064423A1 | 2003-08-07 | |||
| WO2004039807A1 | 2004-05-13 |
Foreign References:
| EP0321192A2 | 1989-06-21 | |||
| US6107329A | 2000-08-22 | |||
| US5952322A | 1999-09-14 | |||
| US6399601B1 | 2002-06-04 | |||
| EP0846464A2 | 1998-06-10 | |||
| EP0712844A1 | 1996-05-22 |
Other References:
WERMUTH ET AL: "The Practise of Medicinal Chemistry", PRACTICE OF MEDICINAL CHEMISTRY, XX, XX, 1996, pages 203 - 237, XP002190259
FRESNEDA P M ET AL: "Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 24, June 2000 (2000-06-01), pages 4777 - 4780, XP004205617, ISSN: 0040-4039
YAKHONTOV L N ET AL: "ABOUT REACTIVITY OF ISOMERIC AZAINDOLES", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, no. 24, 1 May 1969 (1969-05-01), pages 1909 - 1912, XP000575941, ISSN: 0040-4039
FRYDMAN B ET AL: "PYRROLES FROM AZAINDOLES. A SYNTHESIS OF PORPHOBILINOGEN AND RELATED PYRROLES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 91, no. 9, 23 April 1969 (1969-04-23), pages 2338 - 2342, XP002928165, ISSN: 0002-7863
MONNET, MARIE ODILE ET AL: "Synthesis of chiral NADH model compounds in the pyrrolo[3,2-b]pyridine series: models with a chiral group on the pyrrole nitrogen or on the carboxamide side chain", TETRAHEDRON , 49(26), 5831-44 CODEN: TETRAB; ISSN: 0040-4020, 1993, XP002303902
FRESNEDA P M ET AL: "Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 24, June 2000 (2000-06-01), pages 4777 - 4780, XP004205617, ISSN: 0040-4039
YAKHONTOV L N ET AL: "ABOUT REACTIVITY OF ISOMERIC AZAINDOLES", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, no. 24, 1 May 1969 (1969-05-01), pages 1909 - 1912, XP000575941, ISSN: 0040-4039
FRYDMAN B ET AL: "PYRROLES FROM AZAINDOLES. A SYNTHESIS OF PORPHOBILINOGEN AND RELATED PYRROLES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 91, no. 9, 23 April 1969 (1969-04-23), pages 2338 - 2342, XP002928165, ISSN: 0002-7863
MONNET, MARIE ODILE ET AL: "Synthesis of chiral NADH model compounds in the pyrrolo[3,2-b]pyridine series: models with a chiral group on the pyrrole nitrogen or on the carboxamide side chain", TETRAHEDRON , 49(26), 5831-44 CODEN: TETRAB; ISSN: 0040-4020, 1993, XP002303902
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