Title:
QUANTUM DOT-ENHANCED TUMOR INACTIVATED VACCINE, PREPARATION METHOD, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/274297
Kind Code:
A1
Abstract:
Provided are a quantum dot-enhanced tumor inactivated vaccine, a preparation method, and an application. Under the action of heat, a spatial structure of a protein molecule chain on a tumor cell is opened, the protein molecule chain is loosened and a gap is formed, a small quantum dot enters into a spatial conformation of the protein, and a hydrogen bond is formed by means of a functional group at the surface of the quantum dot and a group on the protein molecule chain, and thereby a quantum dot modified inactivated cancer cell complex is formed. The provided inactivated vaccine preserves the primary structure of a cancer cell antigen, i.e. an amino acid sequence is not destroyed, while increasing a specific anti-tumor immune response of capture, presentation, and induction of the cancer cell antigen protein by the immune system. The provided quantum dot-enhanced cancer cell inactivated vaccine can be applied in personalized cancer immunotherapy.
Inventors:
QU SONGNAN (CN)
TANG ZIKANG (CN)
LIANG TAO (CN)
TANG ZIKANG (CN)
LIANG TAO (CN)
Application Number:
PCT/CN2022/102375
Publication Date:
January 05, 2023
Filing Date:
June 29, 2022
Export Citation:
Assignee:
UNIV MACAU (CN)
International Classes:
A61K39/00; A61P35/00; B82Y30/00; C01B32/15
Foreign References:
| CN113476594A | 2021-10-08 | |||
| CN113440607A | 2021-09-28 | |||
| CN113456809A | 2021-10-01 | |||
| CN103013490A | 2013-04-03 | |||
| CN108567978A | 2018-09-25 | |||
| CN108030919A | 2018-05-15 | |||
| CN109876137A | 2019-06-14 |
Other References:
TANG ZIKANG, LIANG TAO, LEI JOSH HAIPENG, GAO HANLU, ZHOU YINNING, LIU YOUCHENG, LIU ENSHAN, ZHANG BOHAN, ZHANG HUIQI, QIAN LUO KA: "Cancer Immunotherapy Based on Carbon-Quantum- Dot Modied Cancer Cells", RESEARCH SQUARE, 26 April 2021 (2021-04-26), XP093017859, Retrieved from the Internet [retrieved on 20230125], DOI: 10.21203/rs.3.rs-457550/v1
SALEEM JABRAN, WANG LIMING, CHEN CHUNYING: "Carbon‐Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 7, no. 20, 24 October 2018 (2018-10-24), DE , pages e1800525 - n/a, XP009542221, ISSN: 2192-2640, DOI: 10.1002/adhm.201800525
LIANG TAO, LIU ENSHAN, LI MINGHUI, USHAKOVA ELENA V., KERSHAW STEPHEN V., ROGACH ANDREY L., TANG ZIKANG, QU SONGNAN: "Morphology Control of Luminescent Carbon Nanomaterials: From Dots to Rolls and Belts", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 1, 26 January 2021 (2021-01-26), US , pages 1579 - 1586, XP093019253, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c09053
SALEEM JABRAN, WANG LIMING, CHEN CHUNYING: "Carbon‐Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 7, no. 20, 24 October 2018 (2018-10-24), DE , pages e1800525 - n/a, XP009542221, ISSN: 2192-2640, DOI: 10.1002/adhm.201800525
LIANG TAO, LIU ENSHAN, LI MINGHUI, USHAKOVA ELENA V., KERSHAW STEPHEN V., ROGACH ANDREY L., TANG ZIKANG, QU SONGNAN: "Morphology Control of Luminescent Carbon Nanomaterials: From Dots to Rolls and Belts", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 1, 26 January 2021 (2021-01-26), US , pages 1579 - 1586, XP093019253, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c09053
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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