Title:
QUINAZOLINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/060114
Kind Code:
A1
Abstract:
A compound, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof, provided as one aspect of the present invention, exhibits a high inhibitory ability on euchromatic histone-lysine N-methyltransferase 2 (EHMT2), and thus, the compound can be usefully used for the treatment of cancer.
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Inventors:
HWANG JUNG JIN (KR)
PARK SANG EUN (KR)
KIM DONG EUN (KR)
HONG JI-YE (KR)
KIM CHOUNG-SOO (KR)
SON WOO CHAN (KR)
KIM SHINAE (KR)
KWON SUGYEONG (KR)
JUNG KYUNGJIN (KR)
KIM NAYEON (KR)
KIM JINA (KR)
KIM KYUNG-HEE (KR)
CHIN JUNG WOOK (KR)
CHO SUNG JIN (KR)
LEE SEHAN (KR)
CHA EUNJU (KR)
JOO JEONGMIN (KR)
HWANG JI SUN (KR)
PARK JEONG-EUN (KR)
YU JI HOON (KR)
HONG EUNMI (KR)
PARK YOUNG-HOON (KR)
LEE JU-HEE (KR)
PARK SANG EUN (KR)
KIM DONG EUN (KR)
HONG JI-YE (KR)
KIM CHOUNG-SOO (KR)
SON WOO CHAN (KR)
KIM SHINAE (KR)
KWON SUGYEONG (KR)
JUNG KYUNGJIN (KR)
KIM NAYEON (KR)
KIM JINA (KR)
KIM KYUNG-HEE (KR)
CHIN JUNG WOOK (KR)
CHO SUNG JIN (KR)
LEE SEHAN (KR)
CHA EUNJU (KR)
JOO JEONGMIN (KR)
HWANG JI SUN (KR)
PARK JEONG-EUN (KR)
YU JI HOON (KR)
HONG EUNMI (KR)
PARK YOUNG-HOON (KR)
LEE JU-HEE (KR)
Application Number:
PCT/KR2021/012661
Publication Date:
March 24, 2022
Filing Date:
September 16, 2021
Export Citation:
Assignee:
ASAN FOUND (KR)
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C07D401/14; A23L33/10; A61K31/517; A61K31/5377; A61K31/55; A61P35/00; C07D401/12
Domestic Patent References:
| WO2008086462A2 | 2008-07-17 | |||
| WO2010081881A1 | 2010-07-22 | |||
| WO2003048152A2 | 2003-06-12 |
Foreign References:
| US20200054635A1 | 2020-02-20 |
Other References:
LEENDERS RUBEN; ZIJLMANS REMCO; VAN BREE BART; VAN DE SANDE MARC; TRIVARELLI FEDERICA; DAMEN EDDY; WEGERT ANITA; MüLLER DANIE: "Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 17, 14 June 2019 (2019-06-14), AMSTERDAM, NL , pages 2516 - 2524, XP085784088, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2019.06.012
LIU ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 8931 - 8942
KRIVEGAET, BLOOD, vol. 126, no. 5, 2015, pages 665 - 672
SANG EUN PARK ET AL., INHIBITION OF EHMT2/G9A, 2016
YUNHA KIM ET AL., BIX-01294, 2013
LIU ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 8931 - 8942
KRIVEGAET, BLOOD, vol. 126, no. 5, 2015, pages 665 - 672
SANG EUN PARK ET AL., INHIBITION OF EHMT2/G9A, 2016
YUNHA KIM ET AL., BIX-01294, 2013
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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