Title:
QUINAZOLINE-3-ALKANOIC ACID DERIVATIVE, SALT THEREOF, AND PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/1991/009024
Kind Code:
A1
Abstract:
A quinazoline-3-alkanoic acid derivative of general formula (I), which has both of platelet agglutination inhibition and aldose reductase inhibition activities, salts thereof, process for producing the same, and a medicine containing the same, wherein R represents hydrogen or a protective group of the carboxyl group; R' represents lower alkyl, alkenyl, alkynyl, lower alkoxy, lower alkylthio, halogen, phenyl (which may be substituted with 1 to 3 substituents selected from among lower alkyl, lower alkoxy, halogen, trifluoromethyl, carboxyethylene, and ethoxy-carbonylethylene groups), naphthyl, heterocycle (which may be substituted with 1 to 3 lower alkyl groups), cycloalkyl, or benzoyl (which may be substituted with lower alkyl or halogen); R2 and R3 may be the same or different from each other and each represents hydrogen, halogen, lower alkyl, lower alkoxy, optionally substituted aralkyl, nitro, imidazolyl, imidazolylmethyl, or -NR4R5 wherein R4 and R5 may be the same or different from each other and each represents hydrogen or lower alkyl, or they are combined with each other to form a 5- or 6-membered heterocycle which may contain other heteroatom(s); X represents carbonyl, thiocarbonyl or methylene (which may be substituted with lower alkyl); A represents lower alkylene or lower alkenylene; and n is an integer of 1 to 3.
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Inventors:
FUJIMORI SHIZUYOSHI (JP)
OHNOTA MICHIRO (JP)
HIRATA YOSHIHIRO (JP)
MURAKAMI KOJI (JP)
OHNOTA MICHIRO (JP)
HIRATA YOSHIHIRO (JP)
MURAKAMI KOJI (JP)
Application Number:
PCT/JP1990/001600
Publication Date:
June 27, 1991
Filing Date:
December 10, 1990
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
International Classes:
A61K31/505; A61K31/517; A61P3/08; A61P3/10; A61P7/02; A61P43/00; C07D239/80; C07D239/95; C07D239/96; C07D401/06; C07D403/04; C07D403/06; C07D405/06; C07D409/06; C07D413/06; C07D417/04; C07D417/06; C07D491/056; C07D521/00; C12N9/99; (IPC1-7): A61K31/505; C07D239/80; C07D239/95; C07D239/96; C07D401/06; C07D403/04; C07D403/06; C07D405/06; C07D409/06; C07D413/06
Foreign References:
| JPS5795966A | 1982-06-15 |
Other References:
See also references of EP 0456835A4
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