Title:
QUINAZOLINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/209039
Kind Code:
A1
Abstract:
The present invention provides a quinazoline compound, a preparation method therefor and an application thereof, and specifically relates to a compound represented by formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt thereof, and a prodrug thereof, a preparation method therefor and an application thereof in the preparation of a drug that acts as a tyrosine kinase inhibitor. The compound in the present invention has good inhibitory activity on EGFR and HER2 kinase, and exhibits excellent performance of passing through the blood-brain barrier at the same time.
More Like This:
| WO/2014/118737 | ERLOTINIB SALTS |
| WO/1996/033978 | QUINAZOLINE DERIVATIVE |
| WO/2002/016351 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS |
Inventors:
ZHANG QIANG (CN)
YANG LEIFU (CN)
YANG LEIFU (CN)
Application Number:
PCT/CN2021/087774
Publication Date:
October 21, 2021
Filing Date:
April 16, 2021
Export Citation:
Assignee:
BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN)
International Classes:
C07D239/94; A61K31/517; A61P1/16; A61P9/10; A61P11/00; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P37/00; C07D401/02
Domestic Patent References:
| WO2020057511A1 | 2020-03-26 | |||
| WO2003081210A2 | 2003-10-02 |
Foreign References:
| CN103998040A | 2014-08-20 | |||
| CN110343090A | 2019-10-18 | |||
| CN1218456A | 1999-06-02 |
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
Download PDF: