QUINAZOLINE DERIVATIVES,PREPARATION METHODS AND USES THEREOF

Title:

QUINAZOLINE DERIVATIVES,PREPARATION METHODS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2007/082434

Kind Code:

A1

Abstract:

The present application has disclosed quinazoline derivatives of formula (I)in which definitions of substituents are the same as description and their pharmaceutically acceptable salts or solvoates . The present application has also disclosed preparation methods and compositions containing the same and their uses in preparation of medicament for treating antineoplastic diseases.

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Inventors:

GUO JIANHUI (CN)
WANG MENG (CN)
JIANG YONG (CN)
ZHANG XIAOFANG (CN)

Application Number:

PCT/CN2006/002786

Publication Date:

July 26, 2007

Filing Date:

October 20, 2006

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Assignee:

SHANGHAI ALLIST PHARMACEUTICAL (CN)
GUO JIANHUI (CN)
WANG MENG (CN)
JIANG YONG (CN)
ZHANG XIAOFANG (CN)

International Classes:

C07D239/94; A61K31/505; A61K31/506; A61K31/517; A61P35/00; C07D401/10; C07D401/12; C07D401/14; C07D403/02; C07D403/04; C07D403/10; C07D403/12; C07D405/00; C07D405/10; C07D405/14; C07D413/10; C07D413/12

Domestic Patent References:

WO2005040125A1	2005-05-06
WO1996030347A1	1996-10-03
WO1997038983A1	1997-10-23
WO2000006555A1	2000-02-10
WO1999035146A1	1999-07-15
WO2006071017A1	2006-07-06

Foreign References:

CN1100046C	2003-01-29
EP0520722A1	1992-12-30
EP0566226A1	1993-10-20
EP0635498A1	1995-01-25

Other References:

BLACKLEDGE G. ET AL.: "Anti-EGF receptor therapy", PROSTATE CANCER AND PROSTATIC DISEASES, vol. 3, no. 4, 2000, pages 296 - 302, XP008126292
BASELGA J. ET AL.: "ZD1839 ("Iressa) as an anticancer agent", DRUGS, vol. 60, no. SUPPL. 1, 2000, pages 33 - 40
DENNY W.A.: "The 4-anilinoquinazoline class of inhibitors of the erbB family of receptor tyrosine kinases", IL FARMACO, vol. 56, 2001, pages 51 - 56, XP003015967
See also references of EP 1990337A4

Attorney, Agent or Firm:

SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (435 Guiping Road, Shanghai 3, CN)

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