Title:
QUINOLINE-BASED HISTONE DEACETYLASE INHIBITORY SUBSTANCES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/219456
Kind Code:
A1
Abstract:
The present invention relates to a quinoline derivative, a preparation method therefor, and a pharmaceutical composition including same as an active ingredient for the prevention or treatment of cancer, autoimmune diseases, fibrosis, and neurodegenerative diseases. The compound represented by Chemical Formula 1, described in the description, selectively inhibits HDAC6 and HDAC8 and exhibits excellent efficacy, and as such, the compound is expected to be advantageously used for preventing or treating cancer, autoimmune diseases, fibrosis, and neurodegenerative diseases.
Inventors:
JEON RAOK (KR)
CHO HYEWON (KR)
YOON HYE JI (KR)
SHIN HYE RAN (KR)
JEON YUESONG (KR)
CHO HYEWON (KR)
YOON HYE JI (KR)
SHIN HYE RAN (KR)
JEON YUESONG (KR)
Application Number:
PCT/KR2023/006467
Publication Date:
November 16, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
UNIV SOOKMYUNG WOMENS IND ACAD COOP FOUND (KR)
International Classes:
C07D401/04; A23L33/10; A61K31/4709; A61P25/28; A61P35/00; A61P37/00; A61P43/00; C07D215/14; C07D409/04
Domestic Patent References:
| WO2004076386A2 | 2004-09-10 | |||
| WO2007093827A1 | 2007-08-23 | |||
| WO2014117090A1 | 2014-07-31 |
Foreign References:
| KR20190141180A | 2019-12-23 |
Other References:
DATABASE Registry 29 March 2018 (2018-03-29), "4-Quinolinepropanamid e, N-hydroxy- (CA IN DEX NAME)", XP093107752, retrieved from STN Database accession no. 2201507-27-7
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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