Title:
QUINOLINE COMPOUND SALT OR CRYSTAL FORM, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/188758
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine; provided are a quinoline compound salt or crystal form, a preparation method therefor, and an application thereof. The quinoline compound is as shown in formula (I), and the provided salt may be used as an inhibitor of phosphoinositide 3-kinase for the treatment of diseases related to phosphoinositide 3-kinase. More specifically, the compound of formula (I) may be 2,4-diamino-6-[1-(7-fluoro-2-pyridin-2-yl-quinolin-3-yl)-ethylamino ]-pyrimidin-5-carbonitrile (compound A), the structure thereof being as shown below: the crystal form I of the p-toluenesulphonate of said compound may be used as an inhibitor of phosphoinositide 3-kinase for the treatment of diseases related to phosphoinositide 3-kinase.
Inventors:
HAO XIAOLIN (US)
Application Number:
PCT/CN2022/079640
Publication Date:
September 15, 2022
Filing Date:
March 08, 2022
Export Citation:
Assignee:
NANJING ZHENGXIANG PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D401/04; C07C303/32; C07C309/04; C07D401/14; A61K31/506; A61P35/00
Foreign References:
| CN108290898A | 2018-07-17 | |||
| US20090023761A1 | 2009-01-22 |
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
Download PDF: