Title:
QUINOLINE DERIVATIVE AS DIAGNOSTIC PROBE FOR DISEASE WITH TAU PROTEIN ACCUMULATION
Document Type and Number:
WIPO Patent Application WO/2004/054978
Kind Code:
A1
Abstract:
It is intended to provide a compound to be used as an imaging diagnosis probe for a disease with tau protein accumulation, its salt or a solvate thereof, and a composition and a kit containing the same. It is also intended to provide a staining method for neurofibrillary tangle in a brain material and a medicinal composition for preventing and/or treating a disease caused or partly caused by a β-sheet structure of protein.
Inventors:
KUDO YUKITSUKA (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
Application Number:
PCT/JP2003/015269
Publication Date:
July 01, 2004
Filing Date:
November 28, 2003
Export Citation:
Assignee:
BF RES INST INC (JP)
KUDO YUKITSUKA (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
KUDO YUKITSUKA (JP)
SUZUKI MASAKO (JP)
SUEMOTO TAKAHIRO (JP)
OKAMURA NOBUYUKI (JP)
SHIOMITSU TSUYOSHI (JP)
SHIMAZU HIROSHI (JP)
International Classes:
A61K31/47; A61K31/473; A61K51/04; A61P25/00; A61P25/28; C07D215/12; C07D215/52; C07D221/10; (IPC1-7): C07D215/12; A61K31/47; A61K31/473; A61K49/00; A61P25/00; A61P25/28; C07D215/52; C07D221/10
Domestic Patent References:
WO1997015308A1 | 1997-05-01 | |||
WO2001070667A1 | 2001-09-27 |
Foreign References:
EP0034490A2 | 1981-08-26 |
Other References:
MIYADERA, T: "Studies on quinolizinium salts-VI. The reaction of quinolizinium ion with aniline.", TETRAHEDRON, vol. 25, no. 4, 1969, pages 837 - 845, XP002060231
TOMISAWA, H ET AL: "Studies on 1-alkyl-2(1H9-pyridinone Derivatives. XVIII. Reaction of 1-Methyl-2 (1H)-quinolone with Phosphoryl Chloride and N,N-Dimethylaniline.", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 21, no. 12, 1973, pages 2606 - 2606, XP002977495
VASIL'EVA, S.A.: "Synthesis of N-tetrahydropyranyl-S-methyl methioninesulphonium salts with substituted cinchoninic acids.", BASHKIRSKII KHIMICHESKII ZHURNAL, vol. 8, no. 4, 2001, pages 10 - 13, XP002977496
DATABASE CHEMCATS [online] "4-Quinolinecarboxylic acid, 2-(4-aminophenyl)-6-bromo-, hydrazide.", XP002977498, Database accession no. 2002:524574
DATABASE REGISTRY [online] "2-(4-Amino-phenyl)-quinoline-4-carboxylic acid.", XP002977497, Database accession no. 94208-62-6
SHEINKMAN, A.K.: "Reactions of cycloammonium cations VII. Quinolination of 1-Alkyl-2,3-Dihydrindoles and 1-Alkyl-1,2,3,4-tetrahydroquinolines.", KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, vol. 11, 1970, pages 1515 - 1521, XP002977499
DATABASE CHEMCATS [online] "Benzenamine, 4-benzo[f] quinolin-3-yl-N,N-diethyl.", XP002977500, Database accession no. 2003:3869884
DATABASE CHEMCATS [online] "3,4-Dihydro-3(4-(dimethylamino)PHenyl) benzo (f) Quinoline", XP002978015, Database accession no. 2000:483750
TOMISAWA, H ET AL: "Studies on 1-alkyl-2(1H9-pyridinone Derivatives. XVIII. Reaction of 1-Methyl-2 (1H)-quinolone with Phosphoryl Chloride and N,N-Dimethylaniline.", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 21, no. 12, 1973, pages 2606 - 2606, XP002977495
VASIL'EVA, S.A.: "Synthesis of N-tetrahydropyranyl-S-methyl methioninesulphonium salts with substituted cinchoninic acids.", BASHKIRSKII KHIMICHESKII ZHURNAL, vol. 8, no. 4, 2001, pages 10 - 13, XP002977496
DATABASE CHEMCATS [online] "4-Quinolinecarboxylic acid, 2-(4-aminophenyl)-6-bromo-, hydrazide.", XP002977498, Database accession no. 2002:524574
DATABASE REGISTRY [online] "2-(4-Amino-phenyl)-quinoline-4-carboxylic acid.", XP002977497, Database accession no. 94208-62-6
SHEINKMAN, A.K.: "Reactions of cycloammonium cations VII. Quinolination of 1-Alkyl-2,3-Dihydrindoles and 1-Alkyl-1,2,3,4-tetrahydroquinolines.", KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, vol. 11, 1970, pages 1515 - 1521, XP002977499
DATABASE CHEMCATS [online] "Benzenamine, 4-benzo[f] quinolin-3-yl-N,N-diethyl.", XP002977500, Database accession no. 2003:3869884
DATABASE CHEMCATS [online] "3,4-Dihydro-3(4-(dimethylamino)PHenyl) benzo (f) Quinoline", XP002978015, Database accession no. 2000:483750
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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