QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE

Title:

QUINOLINE DERIVATIVE HAVING AZOLYL GROUP AND QUINAZOLINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2002/088110

Kind Code:

A1

Abstract:

A compound having strong antitumor activity. It is a compound represented by the formula (I) or a pharmaceutically acceptable salt or solvate thereof: (I) wherein X and Z each represents CH or nitrogen; Y represents oxygen or sulfur; R?1¿, R?2¿, and R?3¿ each represents hydrogen, alkoxy, etc.; R?4¿ represents hydrogen; R?5¿, R?6¿, R?7¿, and R?8¿ each represents hydrogen, halogeno, alkoxy, etc.; R?9¿ and R?10¿ each represents hydrogen, alkyl, etc.; and R?11¿ represents optionally substituted azolyl.

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Inventors:

KUBO KAZUO (JP)
SAKAI TERUYUKI (JP)
NAGAO RIKA (JP)
FUJIWARA YASUNARI (JP)
ISOE TOSHIYUKI (JP)
HASEGAWA KAZUMASA (JP)

Application Number:

PCT/JP2002/004279

Publication Date:

November 07, 2002

Filing Date:

April 26, 2002

Export Citation:

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Assignee:

KIRIN BREWERY (JP)
KUBO KAZUO (JP)
SAKAI TERUYUKI (JP)
NAGAO RIKA (JP)
FUJIWARA YASUNARI (JP)
ISOE TOSHIYUKI (JP)
HASEGAWA KAZUMASA (JP)

International Classes:

C07D401/12; A61K31/4709; A61K31/517; A61P3/10; A61P9/10; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; C07D403/12; C07D413/12; C07D417/12; (IPC1-7): C07D401/12; C07D403/12; C07D413/12; C07D417/12; A61K31/4709; A61K31/517; A61P3/10; A61P9/10; A61P17/06; A61P19/02; A61P29/00; A61P35/00

Domestic Patent References:

WO2002032872A1	2002-04-25
WO2001047890A1	2001-07-05
WO2000043366A1	2000-07-27
WO1997017329A1	1997-05-15
WO1999032106A1	1999-07-01
WO1999032111A1	1999-07-01

Other References: