Title:
QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2001/047890
Kind Code:
A1
Abstract:
Compounds effective in the treatment of diseases caused via autophosphorylation of PDGF receptor, particularly compounds useful as intimal thickening inhibitor. Specifically, compounds of the general formula (I) or pharmacologically acceptable salts or solvates of the same wherein R?1¿ and R?2¿ are each hydrogen, alkyl, or the like; R?3¿, R?4¿, R?5¿ and R?6¿ are each hydrogen, halogeno, alkyl, alkoxy, or the like; R?11¿ and R?12¿ are each hydrogen, alkyl, alkylcarbonyl, or the like; and A is a group represented by any of the general formulae (i) to (x), with the proviso that compounds of the general formula (I) wherein R?3¿, R?4¿, R?5¿ and R?6¿ are each hydrogen and A is a group (v) (wherein u is 0 and R?19¿ is phenyl which may be substituted with halogeno, alkyl, or alkoxy) are excepted.
More Like This:
Inventors:
SAKAI TERUYUKI (JP)
SENGA TERUHUMI (JP)
FURUTA TAKAYUKI (JP)
MIWA ATUSHI (JP)
SENGA TERUHUMI (JP)
FURUTA TAKAYUKI (JP)
MIWA ATUSHI (JP)
Application Number:
PCT/JP2000/009157
Publication Date:
July 05, 2001
Filing Date:
December 22, 2000
Export Citation:
Assignee:
KIRIN BREWERY (JP)
SAKAI TERUYUKI (JP)
SENGA TERUHUMI (JP)
FURUTA TAKAYUKI (JP)
MIWA ATUSHI (JP)
SAKAI TERUYUKI (JP)
SENGA TERUHUMI (JP)
FURUTA TAKAYUKI (JP)
MIWA ATUSHI (JP)
International Classes:
A61K31/47; A61K31/4709; A61K31/496; A61K31/505; A61K31/517; A61K31/5377; A61P9/10; A61P43/00; C07D215/233; C07D233/88; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D521/00; C07D215/22; (IPC1-7): C07D215/233; C07D239/88; C07D401/12; C07D403/12; C07D405/12; A61K31/47; A61K31/496; A61K31/5377; A61K31/505; A61K31/4709; A61K31/517; A61P43/00; A61P9/10
Domestic Patent References:
| WO2000043366A1 | 2000-07-27 | |||
| WO1997017329A1 | 1997-05-15 |
Foreign References:
| EP0860433A1 | 1998-08-26 | |||
| US5480883A | 1996-01-02 |
Other References:
KUBO KAZUO ET AL.: "A novel series of 4-phenoxyquinolines: Potent and highly selective inhibitors of PDGF receptor autophosphorylation", BIOORG. MED. CHEM. LETT., vol. 7, no. 23, 1997, pages 2935 - 2940, XP002937890
WRIGHT GEORGE C. ET AL.: "Synthesis and hypotensive properties of new 4-aminoquinolines", J. MED. CHEM., vol. 14, no. 11, 1971, pages 1060 - 1066, XP002937891
ALSAIDI HATTAB ET AL.: "Convenient synthesis of heteroarylphenyl ethers from chloropyridines and chloroquinolines using phase-transfer catalysis", SYNTHESIS, no. 11, 1980, pages 921 - 924, XP002937892
CHEMICAL ABSTRACTS, vol. 58, 1960, Columbus, Ohio, US; abstract no. 4563E, TIEFENTHAL H.E.: "Substituted phenylquinazolyl ethers" XP002937893
N. ENGL. J. MED., vol. 295, 1976, pages 369
G.A.A. FERNS ET AL., SCIENCE, vol. 253, 1991, pages 1129
M.G. SIROIS ET AL., CIRCULATION, vol. 95, 1997, pages 669
M. UEDA ET AL., AM. J. PATHOL., vol. 149, 1996, pages 831
THE FASEB JOURNAL, vol. 11, 1997, pages 1119 - 1126
See also references of EP 1243582A4
WRIGHT GEORGE C. ET AL.: "Synthesis and hypotensive properties of new 4-aminoquinolines", J. MED. CHEM., vol. 14, no. 11, 1971, pages 1060 - 1066, XP002937891
ALSAIDI HATTAB ET AL.: "Convenient synthesis of heteroarylphenyl ethers from chloropyridines and chloroquinolines using phase-transfer catalysis", SYNTHESIS, no. 11, 1980, pages 921 - 924, XP002937892
CHEMICAL ABSTRACTS, vol. 58, 1960, Columbus, Ohio, US; abstract no. 4563E, TIEFENTHAL H.E.: "Substituted phenylquinazolyl ethers" XP002937893
N. ENGL. J. MED., vol. 295, 1976, pages 369
G.A.A. FERNS ET AL., SCIENCE, vol. 253, 1991, pages 1129
M.G. SIROIS ET AL., CIRCULATION, vol. 95, 1997, pages 669
M. UEDA ET AL., AM. J. PATHOL., vol. 149, 1996, pages 831
THE FASEB JOURNAL, vol. 11, 1997, pages 1119 - 1126
See also references of EP 1243582A4
Attorney, Agent or Firm:
Sato, Kazuo (Fuji Bldg. 2-3 Marunouchi 3-chome Chiyoda-ku, Tokyo, JP)
Download PDF:
Previous Patent: $g(b)-AMINO ACID COMPOUNDS AS INTEGRIN ANTAGONISTS
Next Patent: HETEROCYCLIC COMPOUNDS HAVING SULFONAMIDE GROUPS
Next Patent: HETEROCYCLIC COMPOUNDS HAVING SULFONAMIDE GROUPS