QUINOLINOMORPHINANE DERIVATIVES AND MEDICINAL USE THEREOF

Title:

QUINOLINOMORPHINANE DERIVATIVES AND MEDICINAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/1998/043977

Kind Code:

A1

Abstract:

Quinolinomorphinane derivatives represented by the following general formula (I) or pharmacologically acceptable acid addition salts thereof and remedies and preventives for brain disorders containing the same. In said formula, R?1� represents cyclopropylmethyl, etc.; R?2� and R?3� represent each hydroxy, methoxy, etc.; R?4� represents hydrogen, methyl, amino, etc.; and (R?5�)�m? represents hydrogen, substituted benzo, etc. Because of having excellent preventive effects on cranial nerve cell disorders, these compounds inhibit various ischemic, hemorrhagic or traumatic brain disorders and cranial nerve cell disorders caused by various nerve degenerations and are thus useful as drugs for treating and preventing various brain diseases such as cerebral stroke, traumatic brain diseases, brain edema and cranial nerve degeneration diseases, ameliorating the after troubles of these diseases and preventing the recurrence of the same.

Inventors:

NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
OHNO HIROSHI (JP)
KANEEDA MASANOBU (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)

Application Number:

PCT/JP1998/001443

Publication Date:

October 08, 1998

Filing Date:

March 30, 1998

Export Citation:

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Assignee:

TORAY INDUSTRIES (JP)
NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
OHNO HIROSHI (JP)
KANEEDA MASANOBU (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)

International Classes:

C07D489/00; C07D489/09; C07D491/20; (IPC1-7): C07D489/09; A61K31/485

Domestic Patent References:

WO1989000995A1	1989-02-09
WO1994007896A1	1994-04-14

Foreign References:

JPH03223288A	1991-10-02
JPH03218313A	1991-09-25

Other References: