Title:
RIP1 Inhibitors
Document Type and Number:
WIPO Patent Application WO/2020/103859
Kind Code:
A1
Abstract:
The invention provides amides that inhibit cellular necrosis including corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
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Inventors:
SU YANING (CN)
ZHANG ZHIYUAN (CN)
YANG YI (CN)
WANG GUOZHENG (CN)
LIU WENDONG (CN)
MA YONGFEN (CN)
REN YAN (CN)
ZHANG ZHIYUAN (CN)
YANG YI (CN)
WANG GUOZHENG (CN)
LIU WENDONG (CN)
MA YONGFEN (CN)
REN YAN (CN)
Application Number:
PCT/CN2019/119676
Publication Date:
May 28, 2020
Filing Date:
November 20, 2019
Export Citation:
Assignee:
SU YANING (CN)
SIRONAX LTD (GB)
SIRONAX LTD (GB)
International Classes:
C07C233/05; A61K31/16; A61P25/00; A61P31/00
Domestic Patent References:
| WO2016101885A1 | 2016-06-30 | |||
| WO2018192416A1 | 2018-10-25 | |||
| WO1990001929A1 | 1990-03-08 | |||
| WO2009023272A1 | 2009-02-19 | |||
| WO2010075290A1 | 2010-07-01 | |||
| WO2010075561A1 | 2010-07-01 | |||
| WO2012125544A2 | 2012-09-20 |
Foreign References:
| US4405357A | 1983-09-20 | |||
| US9974762B2 | 2018-05-22 | |||
| US10092529B2 | 2018-10-09 | |||
| US6756394B1 | 2004-06-29 | |||
| US8278344B2 | 2012-10-02 | |||
| US20120122889A1 | 2012-05-17 | |||
| US20090099242A1 | 2009-04-16 | |||
| US20100317701A1 | 2010-12-16 | |||
| US20110144169A1 | 2011-06-16 | |||
| US20030083386A1 | 2003-05-01 | |||
| US20120309795A1 | 2012-12-06 |
Other References:
SITAO ZHANG ET AL.: "RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 116, no. 12, 19 March 2019 (2019-03-19), pages 5675 - 5680, XP055679940
YAN REN ET AL.: "Discovery of a Highly Potent, Selective，and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 3, 9 February 2017 (2017-02-09), pages 972 - 986, XP055435574
DATABASE REGISTRY 5 March 2018 (2018-03-05), retrieved from STN Columbus Database accession no. RN: 2184622-52-2
ANDREA GINI ET AL.: "Dehydrogenative TEMPO-Mediated Formation of Unstable Nitrones: Easy Access to N-Carbamoyl Isoxazolines", CHEMISTRY A EUROPEAN JOURNAL, vol. 21, no. 34, 17 July 2015 (2015-07-17), pages 12053 - 12060, XP055709446
HOLLER ET AL., NAT IMMUNOL, vol. 1, 2000, pages 489 - 495
DEGTEREV ET AL., NAT CHEM BIOL, vol. 4, 2008, pages 313 - 321
DUNAI ET AL., PATHOL. ONCOL. RES.: POR, vol. 17, no. 4, December 2011 (2011-12-01), pages 791 - 800
DEGTEREV ET AL., NAT CHEM BIOL, vol. 1, 2005, pages 112 - 119
MANGUSO ET AL., NATURE, vol. 547, 2017, pages 413 - 418
WANG ET AL., CANCER CELL, vol. 34, 12 November 2018 (2018-11-12), pages 757 - 774
YAN REN ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 3, 9 February 2017 (2017-02-09), pages 972 - 986
"Remington's Pharmaceutical Science", 1991, MACK PUBLISHING CO
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
See also references of EP 3883918A4
YAN REN ET AL.: "Discovery of a Highly Potent, Selective，and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 3, 9 February 2017 (2017-02-09), pages 972 - 986, XP055435574
DATABASE REGISTRY 5 March 2018 (2018-03-05), retrieved from STN Columbus Database accession no. RN: 2184622-52-2
ANDREA GINI ET AL.: "Dehydrogenative TEMPO-Mediated Formation of Unstable Nitrones: Easy Access to N-Carbamoyl Isoxazolines", CHEMISTRY A EUROPEAN JOURNAL, vol. 21, no. 34, 17 July 2015 (2015-07-17), pages 12053 - 12060, XP055709446
HOLLER ET AL., NAT IMMUNOL, vol. 1, 2000, pages 489 - 495
DEGTEREV ET AL., NAT CHEM BIOL, vol. 4, 2008, pages 313 - 321
DUNAI ET AL., PATHOL. ONCOL. RES.: POR, vol. 17, no. 4, December 2011 (2011-12-01), pages 791 - 800
DEGTEREV ET AL., NAT CHEM BIOL, vol. 1, 2005, pages 112 - 119
MANGUSO ET AL., NATURE, vol. 547, 2017, pages 413 - 418
WANG ET AL., CANCER CELL, vol. 34, 12 November 2018 (2018-11-12), pages 757 - 774
YAN REN ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 3, 9 February 2017 (2017-02-09), pages 972 - 986
"Remington's Pharmaceutical Science", 1991, MACK PUBLISHING CO
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
See also references of EP 3883918A4
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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