RNAi TARGETING OF VIRUSES - UNIV MASSACHUSETTS

Title:

RNAi TARGETING OF VIRUSES

Document Type and Number:

WIPO Patent Application WO2004071430

Kind Code:

A3

Abstract:

The invention relates to methods and compositions that inhibit viral replication, e.g., CMV replication, within a host or host cell. Methods and compositions of the invention utilize RNA interference to block the translation of mRNA into proteins which are important or essential to viral replication. The method and compositions can be used to study CMV infection in in vitro cell culture and to treat CMV infection in non-human primates and human subjects.

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Inventors:

KOWALIK TIMOTHY F (US)

Application Number:

PCT/US2004/003544

Publication Date:

February 16, 2006

Filing Date:

February 05, 2004

Export Citation:

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Assignee:

UNIV MASSACHUSETTS (US)
KOWALIK TIMOTHY F (US)

International Classes:

A61K6/00; A61K31/713; A61K48/00; A61P31/20; C07H21/02; C12N15/113; C12N15/38; C12N15/86; A61K; (IPC1-7): A61K48/00; A61K38/17; A61K31/717

Foreign References:

US4689320A	1987-08-25
US20030109450A1	2003-06-12

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