Title:
RADIATION DAMAGE PROTECTION AGENT
Document Type and Number:
WIPO Patent Application WO/2024/009990
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel radiation damage protection agent. The present invention provides a radiation damage protection agent that contains an adipose tissue or an adipose tissue-derived product [for example, a stromal vascular fraction (SVF)], a micronized cellular adipose matrix (MCAM) or an adipose-derived stem/stromal cell (ASC).
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Inventors:
YOSHIMURA KOTARO (JP)
SOWA YOSHIHIRO (JP)
SOWA YOSHIHIRO (JP)
Application Number:
PCT/JP2023/024730
Publication Date:
January 11, 2024
Filing Date:
July 04, 2023
Export Citation:
Assignee:
UNIV JICHI MEDICAL (JP)
International Classes:
A61K35/28; A61K35/35; A61P17/02; A61P39/00
Other References:
MARIA OSAMA MUHAMMAD, SHALABY MOSTAFA, SYME ALASDAIR, ELIOPOULOS NICOLETTA, MUANZA THIERRY: "Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis", CYTOTHERAPY, ISIS MEDICAL MEDIA, OXFORD,, GB, vol. 18, no. 9, 1 September 2016 (2016-09-01), GB , pages 1129 - 1145, XP093125484, ISSN: 1465-3249, DOI: 10.1016/j.jcyt.2016.06.008
MASHIKO, TAKANOBU ET AL.: "Treatment of radiation-induced skin ulcers using topical collagen sponge (RCP) loaded with human adipose stem cells and vascular endothelial progenitor cells", PROGRAM AND ABSTRACTS, RESEARCH COUNCIL MEETING OF JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY, vol. 27, O12-2, 2018, pages 121
SI ZIZHEN, WANG XUE, SUN CHANGHUI, KANG YUCHUN, XU JIAKUN, WANG XIDI, HUI YANG: "Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 114, 25 March 2019 (2019-03-25), FR , pages 108765, XP055963439, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.108765
YOSHIMURA, KOTARO: "Adipose tissue and its progenitor cells: potential roles in regenerative medicine", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 242, no. 4, 1 January 2012 (2012-01-01), JP , pages 315 - 320, XP009552281, ISSN: 0039-2359
FENG JINGWEI, DOI KENTARO, KUNO SHINICHIRO, MINEDA KAZUHIDE, KATO HARUNOSUKE, KINOSHITA KAHORI, KANAYAMA KOJI, MASHIKO TAKANOBU, Y: "Micronized cellular adipose matrix as a therapeutic injectable for diabetic ulcer", REGENERATIVE MEDICINE, FUTURE MEDICINE LTD., GB, vol. 10, no. 6, 1 September 2015 (2015-09-01), GB , pages 699 - 708, XP009551698, ISSN: 1746-0751, DOI: 10.2217/rme.15.48
ASAHI, RINTARO ET AL.: "Pathological analysis and treatment development of definite disorders in radiation therapy", PROGRAM AND ABSTRACTS, RESEARCH COUNCIL MEETING OF JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY, vol. 30, SY3-3, 2021, pages 67
SOWA, YOSHIHIRO: "O21-6 Adipose tissue-derived products prevent definitive radiation damage after radiation therapy", RESEARCH COUNCIL MEETING OF JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY; OCTOBER 13-14, 2022, vol. 31, 19 October 2022 (2022-10-19) - 14 October 2022 (2022-10-14), JP, pages 219, XP009552470
SOWA, YOSHIHIRO ET AL.: "Treatment of radiation skin damage using adipose tissue", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 283, no. 2, 8 October 2022 (2022-10-08), JP , pages 144 - 150, XP009551842, ISSN: 0039-2359
SOWA YOSHIHIRO, INAFUKU NAOKI, KISHIDA TSUNAO, MORI MASANORI, MAZDA OSAM, YOSHIMURA KOTARO: "Prophylactic Application of Human Adipose Tissue-Derived Products to Prevent Radiation Disorders.", PLASTIC AND RECONSTRUCTIVE SURGERY, WOLTERS KLUWER HEALTH, US, vol. 151, no. 6, 1 June 2023 (2023-06-01), US , pages 1207 - 1216, XP009551697, ISSN: 0032-1052, DOI: 10.1097/PRS.0000000000010132
MASHIKO, TAKANOBU ET AL.: "Treatment of radiation-induced skin ulcers using topical collagen sponge (RCP) loaded with human adipose stem cells and vascular endothelial progenitor cells", PROGRAM AND ABSTRACTS, RESEARCH COUNCIL MEETING OF JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY, vol. 27, O12-2, 2018, pages 121
SI ZIZHEN, WANG XUE, SUN CHANGHUI, KANG YUCHUN, XU JIAKUN, WANG XIDI, HUI YANG: "Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 114, 25 March 2019 (2019-03-25), FR , pages 108765, XP055963439, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.108765
YOSHIMURA, KOTARO: "Adipose tissue and its progenitor cells: potential roles in regenerative medicine", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 242, no. 4, 1 January 2012 (2012-01-01), JP , pages 315 - 320, XP009552281, ISSN: 0039-2359
FENG JINGWEI, DOI KENTARO, KUNO SHINICHIRO, MINEDA KAZUHIDE, KATO HARUNOSUKE, KINOSHITA KAHORI, KANAYAMA KOJI, MASHIKO TAKANOBU, Y: "Micronized cellular adipose matrix as a therapeutic injectable for diabetic ulcer", REGENERATIVE MEDICINE, FUTURE MEDICINE LTD., GB, vol. 10, no. 6, 1 September 2015 (2015-09-01), GB , pages 699 - 708, XP009551698, ISSN: 1746-0751, DOI: 10.2217/rme.15.48
ASAHI, RINTARO ET AL.: "Pathological analysis and treatment development of definite disorders in radiation therapy", PROGRAM AND ABSTRACTS, RESEARCH COUNCIL MEETING OF JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY, vol. 30, SY3-3, 2021, pages 67
SOWA, YOSHIHIRO: "O21-6 Adipose tissue-derived products prevent definitive radiation damage after radiation therapy", RESEARCH COUNCIL MEETING OF JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY; OCTOBER 13-14, 2022, vol. 31, 19 October 2022 (2022-10-19) - 14 October 2022 (2022-10-14), JP, pages 219, XP009552470
SOWA, YOSHIHIRO ET AL.: "Treatment of radiation skin damage using adipose tissue", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, BIOMEDICAL DRUGS PUBLICATION, JP, vol. 283, no. 2, 8 October 2022 (2022-10-08), JP , pages 144 - 150, XP009551842, ISSN: 0039-2359
SOWA YOSHIHIRO, INAFUKU NAOKI, KISHIDA TSUNAO, MORI MASANORI, MAZDA OSAM, YOSHIMURA KOTARO: "Prophylactic Application of Human Adipose Tissue-Derived Products to Prevent Radiation Disorders.", PLASTIC AND RECONSTRUCTIVE SURGERY, WOLTERS KLUWER HEALTH, US, vol. 151, no. 6, 1 June 2023 (2023-06-01), US , pages 1207 - 1216, XP009551697, ISSN: 0032-1052, DOI: 10.1097/PRS.0000000000010132
Attorney, Agent or Firm:
SIKS & CO. (JP)
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