Title:
RADIATION THERAPY BIOMARKERS
Document Type and Number:
WIPO Patent Application WO/2010/114979
Kind Code:
A3
Abstract:
Materials and methods related to using biomarkers for prediction of response to radiation therapy.
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Inventors:
WANG LIEWEI (US)
WEINSHILBOUM RICHARD M (US)
KALARI KRISHNA (US)
FRIDLEY BROOKE L (US)
QIN YU XIN (US)
WEINSHILBOUM RICHARD M (US)
KALARI KRISHNA (US)
FRIDLEY BROOKE L (US)
QIN YU XIN (US)
Application Number:
PCT/US2010/029592
Publication Date:
April 21, 2011
Filing Date:
April 01, 2010
Export Citation:
Assignee:
MAYO FOUNDATION (US)
WANG LIEWEI (US)
WEINSHILBOUM RICHARD M (US)
KALARI KRISHNA (US)
FRIDLEY BROOKE L (US)
QIN YU XIN (US)
WANG LIEWEI (US)
WEINSHILBOUM RICHARD M (US)
KALARI KRISHNA (US)
FRIDLEY BROOKE L (US)
QIN YU XIN (US)
International Classes:
C12N15/12; C12Q1/68
Other References:
OJIMA ET AL.: "Effectiveness of gene expression profiling for response prediction of rectal cancer to preoperative radiotherapy", J GASTROENTEROL, vol. 42, no. 9, 25 September 2007 (2007-09-25), pages 730 - 736
WILLEMS ET AL.: "Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity", GENES CHROMOSOMES CANCER, vol. 47, no. 2, February 2008 (2008-02-01), pages 137 - 148
SCHEURER ET AL.: "Polymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma", CLIN CANCER RES, vol. 14, no. 20, 15 October 2008 (2008-10-15), pages 6640 - 6646
AZRIA ET AL.: "Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy", CLIN CANCER RES, vol. 14, no. 19, 1 October 2008 (2008-10-01), pages 6284 - 6288
BURRI ET AL.: "Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer", RADIAT RES, vol. 170, no. 1, July 2008 (2008-07-01), pages 49 - 59
SUGA ET AL.: "Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer", INT J RADIAT ONCOL BIOL PHYS, vol. 72, no. 3, 18 April 2008 (2008-04-18), pages 808 - 813
RĂDNINGEN ET AL.: "Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts", RADIOTHER ONCOL, vol. 77, no. 3, 17 November 2005 (2005-11-17), pages 231 - 240
WILLEMS ET AL.: "Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity", GENES CHROMOSOMES CANCER, vol. 47, no. 2, February 2008 (2008-02-01), pages 137 - 148
SCHEURER ET AL.: "Polymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma", CLIN CANCER RES, vol. 14, no. 20, 15 October 2008 (2008-10-15), pages 6640 - 6646
AZRIA ET AL.: "Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy", CLIN CANCER RES, vol. 14, no. 19, 1 October 2008 (2008-10-01), pages 6284 - 6288
BURRI ET AL.: "Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer", RADIAT RES, vol. 170, no. 1, July 2008 (2008-07-01), pages 49 - 59
SUGA ET AL.: "Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer", INT J RADIAT ONCOL BIOL PHYS, vol. 72, no. 3, 18 April 2008 (2008-04-18), pages 808 - 813
RĂDNINGEN ET AL.: "Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts", RADIOTHER ONCOL, vol. 77, no. 3, 17 November 2005 (2005-11-17), pages 231 - 240
Attorney, Agent or Firm:
KAYTOR, Elizabeth, N. et al. (Minneapolis, MN, US)
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