RADIOACTIVE HALOGEN-LABELED PHENYLOXYANILINE DERIVATIVES

Title:

RADIOACTIVE HALOGEN-LABELED PHENYLOXYANILINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2006/092902

Kind Code:

A1

Abstract:

A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R¹ represents a group such as an alkyl group; X¹, X², X³ and X⁴ represent each a hydrogen atom, an alkyl group, an alkoxy group, an alkoxy group carrying ¹¹C introduced thereinto or a radioactive halogen atom, provided that at least one of X¹, X², X³ and X⁴ represents an alkoxy group carrying ¹¹C introduced thereinto or a radioactive halogen atom; which is a compound useful as a PBR ligand having a high affinity and a high selectivity. In in vitro measurement of PBR, a PBR ligand having a high affinity and a high selectivity is labeled with a radioactive halogen nuclear species so as to enable the measurement of PBR in vivo with the use of means including not only PET but also SPECT. Thus, a compound which is useful in early diagnosing, preventing and treating diseases such as Alzheimer type dementia can be obtained.

Inventors:

SUZUKI KAZUTOSHI (JP)
SUHARA TETSUYA (JP)
CHRISTAR HALLDIN (JP)
ZHANG MING-RONG (JP)
NAKAZATO ATSURO (JP)

Application Number:

PCT/JP2005/024075

Publication Date:

September 08, 2006

Filing Date:

December 28, 2005

Export Citation:

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Assignee:

TAISHO PHARMACEUTICAL CO LTD (JP)
NAT INST RADIOLOG (JP)
SUZUKI KAZUTOSHI (JP)
SUHARA TETSUYA (JP)
CHRISTAR HALLDIN (JP)
ZHANG MING-RONG (JP)
NAKAZATO ATSURO (JP)

International Classes:

C07C233/25; A61K51/00; C07B59/00

Foreign References:

JPH11171844A	1999-06-29
JP2002542306A	2002-12-10

Other References:

ZHANG M.-R. ET AL: "Development of a New Radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for PET Imaging of Peripheral Benzodiazepine Receptor in Primate Brain", J.MED.CHEM., vol. 47, 22 April 2004 (2004-04-22), pages 2228 - 2235, XP002997542

Attorney, Agent or Firm:

Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)

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