Title:
RADIOACTIVE MARKER, AND PRECURSOR COMPOUND THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/092830
Kind Code:
A1
Abstract:
A precursor compound of a radioactive marker as shown in formula (I), a radioactive marker thereof, or a pharmaceutically acceptable salt thereof. The radioactive marker is high in water solubility, good in in-vitro stability at room temperature, and high in plasma protein binding rate, and shows high and long-time bone uptake in both in-vivo distribution in mice and development of New Zealand rabbits, and animal experiments show that the development effect is better than that of 99mTc-MDP.
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Inventors:
CHEN YUE (CN)
WANG YINGWEI (CN)
WANG QIXIN (CN)
QIU LIN (CN)
FENG YUE (CN)
WANG LI (CN)
CHEN ZAN (CN)
YANG JIAN (CN)
PENG DENGSAI (CN)
LIU GUANGFU (CN)
XU TINGTING (CN)
XING NAIGUO (CN)
LIU HANXIANG (CN)
WANG YINGWEI (CN)
WANG QIXIN (CN)
QIU LIN (CN)
FENG YUE (CN)
WANG LI (CN)
CHEN ZAN (CN)
YANG JIAN (CN)
PENG DENGSAI (CN)
LIU GUANGFU (CN)
XU TINGTING (CN)
XING NAIGUO (CN)
LIU HANXIANG (CN)
Application Number:
PCT/CN2022/070444
Publication Date:
June 01, 2023
Filing Date:
January 06, 2022
Export Citation:
Assignee:
AFFILIATED HOSPITAL SOUTHWEST MEDICAL UNIV (CN)
International Classes:
C07F9/6524; A61K51/04; A61P35/04
Foreign References:
| US20130296539A1 | 2013-11-07 | |||
| CN107106711A | 2017-08-29 | |||
| US20140073780A1 | 2014-03-13 | |||
| US20140234210A1 | 2014-08-21 |
Attorney, Agent or Firm:
CHENGDU JIUDING TIANYUAN INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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