Title:
RADIOACTIVE TYROSINE DERIVATIVE, METHOD FOR PRODUCING SAME, LABELING AGENT FOR POSITRON IMAGING AND MEDICAL AGENT FOR ASSESSING GRADE OF MALIGNANCY OF TUMOR RESPECTIVELY COMPOSED OF RADIOACTIVE TYROSINE DERIVATIVE, AND METHOD FOR DETECTING TUMOR
Document Type and Number:
WIPO Patent Application WO/2005/115971
Kind Code:
A1
Abstract:
Disclosed is a radioactive tyrosine derivative represented by the formula (I) below or a pharmaceutically acceptable salt thereof. (In the formula, R1 represents a group selected from the group consisting of -11CH3, -11CH2CH3, -CH218F and -CH2CH2CH218F.)
Inventors:
SATO KENGO (JP)
TSUKADA HIDEO (JP)
TSUKADA HIDEO (JP)
Application Number:
PCT/JP2005/009530
Publication Date:
December 08, 2005
Filing Date:
May 25, 2005
Export Citation:
Assignee:
HAMAMATSU PHOTONICS KK (JP)
SATO KENGO (JP)
TSUKADA HIDEO (JP)
SATO KENGO (JP)
TSUKADA HIDEO (JP)
International Classes:
A61K51/00; A61K51/04; C07B59/00; C07C227/16; C07C229/36; C07B53/00; (IPC1-7): C07C229/36; A61K51/00; C07C227/16
Other References:
TANG G. ET AL: "Synthesis and evaluation of O-(3-(18F)fluoropropyl)-L-tyrosine as an oncologic PET tracer.", NUCLEAR MEDICINE AND BIOLOGY., vol. 30, no. 7, 2003, pages 733 - 739, XP004456918
ISHIWATA K. ET AL: "Evaluation of O-(11C)methyl-L-tyrosine and O-(18F)fluoromethyl-L-tyrosine as tumor imaging tracers by PET.", NUCLEAR MEDICINE AND BIOLOGY., vol. 31, no. 2, February 2004 (2004-02-01), pages 191 - 198, XP004495504
VAN LANGEVELDE A. ET AL: "Potential radiopharmaceuticals for the detection of ocular melanoma. Part III. A study with 14C and 11C labelled tyrosine and dihydroxyphenilalanine.", EUROPEAN JOURNAL OF NUCLEAR MEDICINE., vol. 14, no. 7-8, 1988, pages 382 - 387, XP002990934
BOLSTER J.M. ET AL: "Carbon-11 labelled tyrosine to study tumor metabolism by positron emission tomography (PET).", EUROPEAN JOURNAL OF NUCLEAR MEDICINE., vol. 12, no. 7, 1986, pages 321 - 324, XP002990935
WESTER H.J. ET AL: "Synthesis and Radiopharmacology of O-(2-(18F)fluoroethyl)-L-Tyrosine for Tumor Imaging.", JOURNAL OF NUCLEAR MEDICINE., vol. 40, no. 1, 1999, pages 205 - 212, XP002290178
HEISS P. ET AL: "Investigation of Transport Mechanism and Uptake Kinetics of 0-(18F)Fluoroethyl)-L-Tyrosine In Vitro and In Vivo.", JOURNAL OF NUCLEAR MEDICINE., vol. 40, no. 8, 1999, pages 1367 - 1373, XP002290177
See also references of EP 1749815A4
ISHIWATA K. ET AL: "Evaluation of O-(11C)methyl-L-tyrosine and O-(18F)fluoromethyl-L-tyrosine as tumor imaging tracers by PET.", NUCLEAR MEDICINE AND BIOLOGY., vol. 31, no. 2, February 2004 (2004-02-01), pages 191 - 198, XP004495504
VAN LANGEVELDE A. ET AL: "Potential radiopharmaceuticals for the detection of ocular melanoma. Part III. A study with 14C and 11C labelled tyrosine and dihydroxyphenilalanine.", EUROPEAN JOURNAL OF NUCLEAR MEDICINE., vol. 14, no. 7-8, 1988, pages 382 - 387, XP002990934
BOLSTER J.M. ET AL: "Carbon-11 labelled tyrosine to study tumor metabolism by positron emission tomography (PET).", EUROPEAN JOURNAL OF NUCLEAR MEDICINE., vol. 12, no. 7, 1986, pages 321 - 324, XP002990935
WESTER H.J. ET AL: "Synthesis and Radiopharmacology of O-(2-(18F)fluoroethyl)-L-Tyrosine for Tumor Imaging.", JOURNAL OF NUCLEAR MEDICINE., vol. 40, no. 1, 1999, pages 205 - 212, XP002290178
HEISS P. ET AL: "Investigation of Transport Mechanism and Uptake Kinetics of 0-(18F)Fluoroethyl)-L-Tyrosine In Vitro and In Vivo.", JOURNAL OF NUCLEAR MEDICINE., vol. 40, no. 8, 1999, pages 1367 - 1373, XP002290177
See also references of EP 1749815A4
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo 61, JP)
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