Title:
RADIOMETAL COMPLEXES THAT LOCALISE IN HYPOXIC TISSUE
Document Type and Number:
WIPO Patent Application WO1995004552
Kind Code:
A3
Abstract:
PCT No. PCT/GB94/01705 Sec. 371 Date Apr. 9, 1996 Sec. 102(e) Date Apr. 9, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/04552 PCT Pub. Date Feb. 16, 1995Methods of imaging and radiotherapy of hypoxic tissues are provided using radiometal complexes not substituted by a hypoxia-localizing moiety.
Inventors:
ARCHER COLIN MILL (GB)
BURKE JAMES FREDERICK (GB)
CANNING LEWIS REUBEN (GB)
EDWARDS BARBARA (GB)
KING ADAM CHARLES (GB)
BURKE JAMES FREDERICK (GB)
CANNING LEWIS REUBEN (GB)
EDWARDS BARBARA (GB)
KING ADAM CHARLES (GB)
Application Number:
PCT/GB1994/001705
Publication Date:
March 23, 1995
Filing Date:
August 03, 1994
Export Citation:
Assignee:
AMERSHAM INT PLC (GB)
ARCHER COLIN MILL (GB)
BURKE JAMES FREDERICK (GB)
CANNING LEWIS REUBEN (GB)
EDWARDS BARBARA (GB)
KING ADAM CHARLES (GB)
ARCHER COLIN MILL (GB)
BURKE JAMES FREDERICK (GB)
CANNING LEWIS REUBEN (GB)
EDWARDS BARBARA (GB)
KING ADAM CHARLES (GB)
International Classes:
A61K51/00; C07D233/91; A61K51/04; A61P35/00; C07B59/00; C07C251/36; C07C251/38; C07C251/70; C07D233/28; C07F13/00; (IPC1-7): A61K51/04
Foreign References:
| EP0123504A2 | 1984-10-31 | |||
| EP0171984A2 | 1986-02-19 | |||
| EP0179608A2 | 1986-04-30 | |||
| EP0380016A1 | 1990-08-01 | |||
| EP0544412A2 | 1993-06-02 | |||
| EP0417870A2 | 1991-03-20 |
Other References:
GROSHAR D ET AL: "Imaging tumor hypoxia and tumor perfusion.", J NUCL MED, VOL. 34, NO. 6, PAGE(S) 885-8, US, 1993
TROUTNER, DAVID E. ET AL: "A neutral lipophilic complex of technetium-99m with a multidentate amine oxime", INT. J. APPL. RADIAT. ISOT., 1984, VOL. 35, PAGE(S) 467-70
VOLKERT, W. A. ET AL: "99mTc-propylene amine oxime (99mTc-PnAO);a potential brain radiopharmaceutical", EUR. J. NUCL. MED., 1984, VOL. 9, PAGE(S) 511-16
VOLKERT, W. A. ET AL: "The behavior of neutral amine oxime chelates labeled with technetium at tracer level", INT. J. NUCL. MED. BIOL., 1984, VOL. 11, PAGE(S) 243-6
CHAPLIN, S. B. ET AL: "Regional cerebral uptake and retention of technetium-99m-tetramethyl- and pentamethyl-propyleneamine oxime chelates", NUCL. MED. BIOL., 1986, VOL. 13, PAGE(S) 261-7
FOCKELE D.S. ET AL: "Tc-99m HMPAO SPECT of the brain in the neonate", CLIN. NUCL. MED. (US), 1990, VOL. 15, NO. 3, PAGE(S) 175-177,
MOORE RB ET AL: "Measurement of PDT-induced hypoxia in Dunning prostate tumors by iodine-123-iodoazomycin arabinoside [see comments]", J NUCL MED (UNITED STATES), VOL. 34, NO. 3, PAGE(S) 405-11,, 1993
WARE D.C. ET AL: "Design and synthesis of cobalt(III) nitrogen mustard complexes as hypoxia selective cytotoxins. The X-ray crystal structure of bis(3-Chloropentane-2, 4-dionato)(RS-N,N'bis(2-chloroethyl)ethylenediamine) cobalt(III) perchlorate, (Co(Clacac)2(bce))ClO4", J. CHEM. SOC., CHEM. COMMUN. (GB), 1991, NO. 17, PAGE(S) 1171-1173,
DATABASE WPI Derwent World Patents Index; AN 84-072822 [12]
ILCHUL KIM S. ET AL: "A new look at radionuclides therapy in metastatic disease of bone (review and prospects)", ANTICANCER RES. (GR), 1988, VOL. 8, NO. 4, PAGE(S) 681-684,
RUMSEY W L ET AL: "A novel technetium-99m-labeled nitroheterocycle capable of identification of hypoxia in heart", BIOCHEM. BIOPHYS. RES. COMMUN., 1993, VOL. 193, NO. 3, PAGE(S) 1239-46
LINDER K E ET AL: "CHEMISTRY OF A TECHNETIUM-PNAO-NITROIMIDAZOLE COMPLEX THAT LOCALIZES IN HYPOXIC TISSUE", 39TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, LOS ANGELES, CALIFORNIA, USA, JUNE 9-12, 1992.
DI ROCCO R J ET AL: "IMAGING REGIONAL HYPOXIA WITH A NEW TECHNETIUM-LABELED IMAGING AGENT IN RABBIT MYOCARDIUM AFTER OCCLUSION OF THE LEFT ANTERIOR DESCENDING CORONARY ARTERY", 39TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, LOS ANGELES, CALIFORNIA, USA, JUNE 9-12, 1992.
LINDER K E ET AL: "TcO(PnAO-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction", J. MED. CHEM., 1994, VOL. 37, NO. 1, PAGE(S) 9-17
TROUTNER, DAVID E. ET AL: "A neutral lipophilic complex of technetium-99m with a multidentate amine oxime", INT. J. APPL. RADIAT. ISOT., 1984, VOL. 35, PAGE(S) 467-70
VOLKERT, W. A. ET AL: "99mTc-propylene amine oxime (99mTc-PnAO);a potential brain radiopharmaceutical", EUR. J. NUCL. MED., 1984, VOL. 9, PAGE(S) 511-16
VOLKERT, W. A. ET AL: "The behavior of neutral amine oxime chelates labeled with technetium at tracer level", INT. J. NUCL. MED. BIOL., 1984, VOL. 11, PAGE(S) 243-6
CHAPLIN, S. B. ET AL: "Regional cerebral uptake and retention of technetium-99m-tetramethyl- and pentamethyl-propyleneamine oxime chelates", NUCL. MED. BIOL., 1986, VOL. 13, PAGE(S) 261-7
FOCKELE D.S. ET AL: "Tc-99m HMPAO SPECT of the brain in the neonate", CLIN. NUCL. MED. (US), 1990, VOL. 15, NO. 3, PAGE(S) 175-177,
MOORE RB ET AL: "Measurement of PDT-induced hypoxia in Dunning prostate tumors by iodine-123-iodoazomycin arabinoside [see comments]", J NUCL MED (UNITED STATES), VOL. 34, NO. 3, PAGE(S) 405-11,, 1993
WARE D.C. ET AL: "Design and synthesis of cobalt(III) nitrogen mustard complexes as hypoxia selective cytotoxins. The X-ray crystal structure of bis(3-Chloropentane-2, 4-dionato)(RS-N,N'bis(2-chloroethyl)ethylenediamine) cobalt(III) perchlorate, (Co(Clacac)2(bce))ClO4", J. CHEM. SOC., CHEM. COMMUN. (GB), 1991, NO. 17, PAGE(S) 1171-1173,
DATABASE WPI Derwent World Patents Index; AN 84-072822 [12]
ILCHUL KIM S. ET AL: "A new look at radionuclides therapy in metastatic disease of bone (review and prospects)", ANTICANCER RES. (GR), 1988, VOL. 8, NO. 4, PAGE(S) 681-684,
RUMSEY W L ET AL: "A novel technetium-99m-labeled nitroheterocycle capable of identification of hypoxia in heart", BIOCHEM. BIOPHYS. RES. COMMUN., 1993, VOL. 193, NO. 3, PAGE(S) 1239-46
LINDER K E ET AL: "CHEMISTRY OF A TECHNETIUM-PNAO-NITROIMIDAZOLE COMPLEX THAT LOCALIZES IN HYPOXIC TISSUE", 39TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, LOS ANGELES, CALIFORNIA, USA, JUNE 9-12, 1992.
DI ROCCO R J ET AL: "IMAGING REGIONAL HYPOXIA WITH A NEW TECHNETIUM-LABELED IMAGING AGENT IN RABBIT MYOCARDIUM AFTER OCCLUSION OF THE LEFT ANTERIOR DESCENDING CORONARY ARTERY", 39TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE, LOS ANGELES, CALIFORNIA, USA, JUNE 9-12, 1992.
LINDER K E ET AL: "TcO(PnAO-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction", J. MED. CHEM., 1994, VOL. 37, NO. 1, PAGE(S) 9-17
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