Title:
RAPID METHOD FOR MEASURING CYTOTOXICITY IN NON-RI SYSTEM
Document Type and Number:
WIPO Patent Application WO/2015/152111
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a novel compound for measuring cytotoxicity or cellular proliferative potential accurately, simply, and rapidly at high reproducibility; and a method for measuring cytotoxicity or cellular proliferative potential using this compound. The present invention pertains to a compound represented by formula (I): (in the formula, R1 represents a substituent, R2 and R3 each represent an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y represents a substituent, m represents an integer of 0-3, Z represents a single bond, -O-, -S-, -SO-, -SO2-, or -NR4- (R4 represents a hydrogen atom or substituent), and A represents an optionally substituted C1-6 alkylene group), or a salt thereof.
Inventors:
TANAKA YOSHIMASA (JP)
SAKAI YUKI (JP)
MIZUTA SATOSHI (JP)
UEDA HIROSHI (JP)
SAKAI YUKI (JP)
MIZUTA SATOSHI (JP)
UEDA HIROSHI (JP)
Application Number:
PCT/JP2015/059838
Publication Date:
October 08, 2015
Filing Date:
March 30, 2015
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
C07D213/79; C12Q1/04; G01N21/78
Domestic Patent References:
| WO1990000550A1 | 1990-01-25 |
Foreign References:
| EP0068875A2 | 1983-01-05 |
Other References:
BLOMBERG K. ET AL.: "Journal of Immunological Methods", vol. 193, no. 2, 1996, pages 199 - 206, XP055359262
HEMMILA I. ET AL.: "Di- and tetracarboxylate derivatives of pyridines, bipyridines and terpyridines as luminogenic reagents for time- resolved fluorometric determination of terbium and dysprosium", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 26, no. 4, 1993, pages 283 - 90, XP025211400
HEMMILA I. ET AL.: "Di- and tetracarboxylate derivatives of pyridines, bipyridines and terpyridines as luminogenic reagents for time- resolved fluorometric determination of terbium and dysprosium", JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, vol. 26, no. 4, 1993, pages 283 - 90, XP025211400
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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