Title:
RAPID MULTIPLE PANEL OF BIOMARKERS IN LABORATORY BLOOD TESTS FOR TIA/STROKE
Document Type and Number:
WIPO Patent Application WO2002012892
Kind Code:
A3
Abstract:
A method, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor or fragment thereof, in a biological sample from a human subject, and optionally measuring other biomarkers such as homocysteine and glutamate. The method is particularly useful for identifying individuals that are at risk for stroke, and for diagnosing stroke in an emergency room setting.
Inventors:
DAMBINOVA SVETLANA A (US)
Application Number:
PCT/US2001/024248
Publication Date:
July 31, 2003
Filing Date:
August 02, 2001
Export Citation:
Assignee:
DAMBINOVA SVETLANA A (US)
CIS BIOTECH INC (US)
CIS BIOTECH INC (US)
International Classes:
G01N33/68; G01N33/94; (IPC1-7): G01N33/94; C07K14/705; G01N33/68
Other References:
MONYER H ET AL: "Heteromeric NMDA receptors: molecular and functional distinction of subtypes.", SCIENCE. UNITED STATES 22 MAY 1992, vol. 256, no. 5060, 22 May 1992 (1992-05-22), pages 1217 - 1221, XP001093645, ISSN: 0036-8075
HESS S D ET AL: "CLONING AND FUNCTIONAL CHARACTERIZATION OF HUMAN HETEROMERIC N-METYL-D-ASPARTATE RECEPTORS", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 278, no. 2, 1 August 1996 (1996-08-01), pages 808 - 816, XP000676640, ISSN: 0022-3565
GUSEV E I ET AL: "Investigation of the level of autoantibodies to glutamate receptors in blood serum of patients in acute period of ischemic stroke.", ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S. S. KORSAKOVA, vol. 96, no. 5, 1996, pages 68 - 72, XP002212398
SKOROMETS ALEXANDER A ET AL: "Autoantibodies to NMDA-receptor fragment in patients with ischemic stroke.", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 150, no. SUPPL., 1997, XVI World Congress of Neurology;Buenos Aires, Argentina; September 14-19, 1997, pages S280, XP001098449, ISSN: 0022-510X
GUSEV E I ET AL: "Neuroprotective effects of glycine for therapy of acute ischaemic stroke.", CEREBROVASCULAR DISEASES (BASEL, SWITZERLAND) SWITZERLAND 2000 JAN-FEB, vol. 10, no. 1, January 2000 (2000-01-01), pages 49 - 60, XP002212399, ISSN: 1015-9770
MELDRUM B S: "Glutamate as a neurotransmitter in the brain: review of physiology and pathology.", THE JOURNAL OF NUTRITION. UNITED STATES APR 2000, vol. 130, no. 4S Suppl, April 2000 (2000-04-01), pages 1007S - 15S, XP001097318, ISSN: 0022-3166
HESS S D ET AL: "CLONING AND FUNCTIONAL CHARACTERIZATION OF HUMAN HETEROMERIC N-METYL-D-ASPARTATE RECEPTORS", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND, US, vol. 278, no. 2, 1 August 1996 (1996-08-01), pages 808 - 816, XP000676640, ISSN: 0022-3565
GUSEV E I ET AL: "Investigation of the level of autoantibodies to glutamate receptors in blood serum of patients in acute period of ischemic stroke.", ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S. S. KORSAKOVA, vol. 96, no. 5, 1996, pages 68 - 72, XP002212398
SKOROMETS ALEXANDER A ET AL: "Autoantibodies to NMDA-receptor fragment in patients with ischemic stroke.", JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 150, no. SUPPL., 1997, XVI World Congress of Neurology;Buenos Aires, Argentina; September 14-19, 1997, pages S280, XP001098449, ISSN: 0022-510X
GUSEV E I ET AL: "Neuroprotective effects of glycine for therapy of acute ischaemic stroke.", CEREBROVASCULAR DISEASES (BASEL, SWITZERLAND) SWITZERLAND 2000 JAN-FEB, vol. 10, no. 1, January 2000 (2000-01-01), pages 49 - 60, XP002212399, ISSN: 1015-9770
MELDRUM B S: "Glutamate as a neurotransmitter in the brain: review of physiology and pathology.", THE JOURNAL OF NUTRITION. UNITED STATES APR 2000, vol. 130, no. 4S Suppl, April 2000 (2000-04-01), pages 1007S - 15S, XP001097318, ISSN: 0022-3166
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