Title:
α-RAY EMITTING ANTIBODY-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2023/054285
Kind Code:
A1
Abstract:
The present disclosure relates to: an α-ray emitting antibody-drug conjugate; a method for producing same; a use thereof; a pharmaceutical composition comprising said α-ray emitting antibody-drug conjugate; and a test, diagnosis, and treatment method.
Inventors:
KABAYAMA KAZUYA (JP)
FUKASE KOICHI (JP)
KADONAGA YUICHIRO (JP)
KANEDA KAZUKO (JP)
MANABE YOSHIYUKI (JP)
SHIMOYAMA ATSUSHI (JP)
SHINOHARA ATSUSHI (JP)
MIZUNO MAMORU (JP)
GOTO KOHTARO (JP)
TSUKIMURA WATARU (JP)
MATSUDA AKIO (JP)
FUKASE KOICHI (JP)
KADONAGA YUICHIRO (JP)
KANEDA KAZUKO (JP)
MANABE YOSHIYUKI (JP)
SHIMOYAMA ATSUSHI (JP)
SHINOHARA ATSUSHI (JP)
MIZUNO MAMORU (JP)
GOTO KOHTARO (JP)
TSUKIMURA WATARU (JP)
MATSUDA AKIO (JP)
Application Number:
PCT/JP2022/035783
Publication Date:
April 06, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
THE NOGUCHI INST (JP)
THE NOGUCHI INST (JP)
International Classes:
A61K39/395; A61K47/68; A61K51/10; A61P35/00; C07K1/113; C07K16/00; C07K16/30
Foreign References:
| JP2018027078A | 2018-02-22 | |||
| JP2015501654A | 2015-01-19 |
Other References:
MITSUHIRO IWAMOTO, TAKAHIRO YAMAGUCHI, YUKIKO SEKIGUCHI, SHOHEI OISHI, TAKESHI SHIIKI, MASAKO SOMA, KENSUKE NAKAMURA, MAKOTO YOSHI: "Pharmacokinetic and Pharmacodynamic Profiles of Glyco-Modified Atrial Natriuretic Peptide Derivatives Synthesized Using Chemo-enzymatic Synthesis Approaches", BIOCONJUGATE CHEMISTRY, vol. 29, no. 8, 15 August 2018 (2018-08-15), US , pages 2829 - 2837, XP055641868, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00427
EＮＧａｓｅ, ＰＥＧ ２, 05 March 2019, p. 174
FUJIKI KATSUMASA, KANAYAMA YOUSUKE, YANO SHINYA, SATO NOZOMI, YOKOKITA TAKUYA, AHMADI PENI, WATANABE YASUYOSHI, HABA HIROMITSU, TA: "211 At-labeled immunoconjugate via a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics", CHEMICAL SCIENCE, vol. 10, no. 7, 13 February 2019 (2019-02-13), United Kingdom , pages 1936 - 1944, XP093053668, ISSN: 2041-6520, DOI: 10.1039/C8SC04747B
WILBUR D. SCOTT, CHYAN MING-KUAN, HAMLIN DONALD K., NGUYEN HOLLY, VESSELLA ROBERT L.: "Reagents for Astatination of Biomolecules. 5. Evaluation of Hydrazone Linkers in 211 At- and 125 I-Labeled closo -Decaborate(2-) Conjugates of Fab′ as a Means of Decreasing Kidney Retention", BIOCONJUGATE CHEMISTRY, vol. 22, no. 6, 15 June 2011 (2011-06-15), US , pages 1089 - 1102, XP093053670, ISSN: 1043-1802, DOI: 10.1021/bc1005625
WILBUR D. SCOTT, THAKAR MONICA S., HAMLIN DONALD K., SANTOS ERLINDA B., CHYAN MING-KUAN, NAKAMAE HIROHISA, PAGEL JOHN M., PRESS OL: "Reagents for Astatination of Biomolecules. 4. Comparison of Maleimido- closo -Decaborate(2-) and meta -[ 211 At]Astatobenzoate Conjugates for Labeling anti-CD45 Antibodies with [ 211 At]Astatine", BIOCONJUGATE CHEMISTRY, vol. 20, no. 10, 21 October 2009 (2009-10-21), US , pages 1983 - 1991, XP093053672, ISSN: 1043-1802, DOI: 10.1021/bc9000799
ALEXANDER KUZMIN, ANDREI POLOUKHTINE, MARGREET A. WOLFERT, VLADIMIR V. POPIK: "Surface Functionalization Using Catalyst-Free Azide-Alkyne Cycloaddition", BIOCONJUGATE CHEMISTRY, vol. 21, no. 11, 17 November 2010 (2010-11-17), pages 2076 - 2085, XP055004644, ISSN: 10431802, DOI: 10.1021/bc100306u
EＮＧａｓｅ, ＰＥＧ ２, 05 March 2019, p. 174
FUJIKI KATSUMASA, KANAYAMA YOUSUKE, YANO SHINYA, SATO NOZOMI, YOKOKITA TAKUYA, AHMADI PENI, WATANABE YASUYOSHI, HABA HIROMITSU, TA: "211 At-labeled immunoconjugate via a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics", CHEMICAL SCIENCE, vol. 10, no. 7, 13 February 2019 (2019-02-13), United Kingdom , pages 1936 - 1944, XP093053668, ISSN: 2041-6520, DOI: 10.1039/C8SC04747B
WILBUR D. SCOTT, CHYAN MING-KUAN, HAMLIN DONALD K., NGUYEN HOLLY, VESSELLA ROBERT L.: "Reagents for Astatination of Biomolecules. 5. Evaluation of Hydrazone Linkers in 211 At- and 125 I-Labeled closo -Decaborate(2-) Conjugates of Fab′ as a Means of Decreasing Kidney Retention", BIOCONJUGATE CHEMISTRY, vol. 22, no. 6, 15 June 2011 (2011-06-15), US , pages 1089 - 1102, XP093053670, ISSN: 1043-1802, DOI: 10.1021/bc1005625
WILBUR D. SCOTT, THAKAR MONICA S., HAMLIN DONALD K., SANTOS ERLINDA B., CHYAN MING-KUAN, NAKAMAE HIROHISA, PAGEL JOHN M., PRESS OL: "Reagents for Astatination of Biomolecules. 4. Comparison of Maleimido- closo -Decaborate(2-) and meta -[ 211 At]Astatobenzoate Conjugates for Labeling anti-CD45 Antibodies with [ 211 At]Astatine", BIOCONJUGATE CHEMISTRY, vol. 20, no. 10, 21 October 2009 (2009-10-21), US , pages 1983 - 1991, XP093053672, ISSN: 1043-1802, DOI: 10.1021/bc9000799
ALEXANDER KUZMIN, ANDREI POLOUKHTINE, MARGREET A. WOLFERT, VLADIMIR V. POPIK: "Surface Functionalization Using Catalyst-Free Azide-Alkyne Cycloaddition", BIOCONJUGATE CHEMISTRY, vol. 21, no. 11, 17 November 2010 (2010-11-17), pages 2076 - 2085, XP055004644, ISSN: 10431802, DOI: 10.1021/bc100306u
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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