Title:
RECEPTOR-INTERACTING PROTEIN 1 INHIBITORS, PREPARATIONS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/194259
Kind Code:
A1
Abstract:
It provides compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, including those mediated by receptor-interacting protein 1 (RIP1) signaling.
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| WO/2004/041258 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS, PREPARATION AND USES |
| WO/2017/112950 | CFTR REGULATORS AND METHODS OF USE THEREOF |
Inventors:
SU YANING (CN)
ZHANG ZHAOLAN (CN)
XU YANPING (CN)
ZHANG ZHIYUAN (CN)
ZHANG ZHAOLAN (CN)
XU YANPING (CN)
ZHANG ZHIYUAN (CN)
Application Number:
PCT/CN2022/081544
Publication Date:
September 22, 2022
Filing Date:
March 17, 2022
Export Citation:
Assignee:
SIRONAX LTD (GB)
SU YANING (CN)
SU YANING (CN)
International Classes:
C07D401/04; A61K31/4439; A61K31/445; A61K31/497; A61P25/00; A61P29/00; A61P31/00; A61P35/00; C07D403/04; C07D403/14; C07D413/04; C07D413/14
Domestic Patent References:
| WO2020103859A1 | 2020-05-28 | |||
| WO2009097474A1 | 2009-08-06 | |||
| WO2012052948A1 | 2012-04-26 | |||
| WO2009049165A1 | 2009-04-16 | |||
| WO2008002247A1 | 2008-01-03 |
Foreign References:
| US20150315209A1 | 2015-11-05 |
Other References:
DATABASE REGISTRY 4 November 2021 (2021-11-04), ANONYMOUS : "-4-Piperidinecarboxamide, 1-[4-(3,5-dimethyl-1-pyrazolidinyl)-2- pyrimidinyl]-N-(4-pyridinylmethyl)-(CA INDEX NAME) ne Chemicals LLC LC -STN Files: CHEMCATS **PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT**", XP055967308, retrieved from STN Database accession no. 2724440-66-6
DATABASE REGISTRY 11 February 2010 (2010-02-11), ANONYMOUS : "-4-Piperidinecarboxamide, N-[(4-fluorophenyl)methyl]-1-(4-phenyl-2- pyrimidinyl)-(CA INDEX NAME) ", XP055967309, retrieved from STN Database accession no. 1205889-89-9 (+ 1227706-28-6， 1031564-96-1， 1031564-99-4， 2096325-64-1， 2096273-88-8， 2096158-04-0， 2096129-43-8， 1775533-19-1， 1775361-14-2)
ZHONG WENHE, KOAY ANN, NGO ANNA, LI YAN, NAH QIANHUI, WONG YEE HWA, CHIONH YOK HIAN, NG HUI QI, KOH-STENTA XIAOYING, POULSEN ANDER: "Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N 1 G37) Methyltransferase (TrmD) Inhibitors", ACS INFECTIOUS DISEASES, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 3, 8 March 2019 (2019-03-08), US , pages 326 - 335, XP055967314, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.8b00275
DATABASE REGISTRY 11 February 2010 (2010-02-11), ANONYMOUS : "-4-Piperidinecarboxamide, N-[(4-fluorophenyl)methyl]-1-(4-phenyl-2- pyrimidinyl)-(CA INDEX NAME) ", XP055967309, retrieved from STN Database accession no. 1205889-89-9 (+ 1227706-28-6， 1031564-96-1， 1031564-99-4， 2096325-64-1， 2096273-88-8， 2096158-04-0， 2096129-43-8， 1775533-19-1， 1775361-14-2)
ZHONG WENHE, KOAY ANN, NGO ANNA, LI YAN, NAH QIANHUI, WONG YEE HWA, CHIONH YOK HIAN, NG HUI QI, KOH-STENTA XIAOYING, POULSEN ANDER: "Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N 1 G37) Methyltransferase (TrmD) Inhibitors", ACS INFECTIOUS DISEASES, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 3, 8 March 2019 (2019-03-08), US , pages 326 - 335, XP055967314, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.8b00275
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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