Title:
RECEPTOR-SELECTIVE LYMPHOTOXIN DEVIANTS
Document Type and Number:
WIPO Patent Application WO/2006/066463
Kind Code:
A1
Abstract:
This invention discloses some receptor-selective lymphotoxin (LT) mutants and the ratio, the ability of these lymphotoxin mutants combining with the human TNFRI to that with the human TNFRII, is more than 10. The preparation method and the use of the above said LT mutants are also disclosed. In this invention, the LT mutants bind to the TNFRI selectively and that decreases the binding to the TNFRII in a large range, thereby the toxic effect which may be caused by the TNFRII will be reduced.
Inventors:
LIU YANJUN (CN)
YANG TONG (CN)
SHEN YIJUN (CN)
WU JINGSONG (CN)
CAO FENG (CN)
WANG ZHENG (CN)
TAN JINGWEI (CN)
WU FANG (CN)
XU YAN (CN)
WANG HAIBO (CN)
YANG TONG (CN)
SHEN YIJUN (CN)
WU JINGSONG (CN)
CAO FENG (CN)
WANG ZHENG (CN)
TAN JINGWEI (CN)
WU FANG (CN)
XU YAN (CN)
WANG HAIBO (CN)
Application Number:
PCT/CN2004/001522
Publication Date:
June 29, 2006
Filing Date:
December 24, 2004
Export Citation:
Assignee:
SHANGHAI FUDAN ZHANGJIANG BIO (CN)
LIU YANJUN (CN)
YANG TONG (CN)
SHEN YIJUN (CN)
WU JINGSONG (CN)
CAO FENG (CN)
WANG ZHENG (CN)
TAN JINGWEI (CN)
WU FANG (CN)
XU YAN (CN)
WANG HAIBO (CN)
LIU YANJUN (CN)
YANG TONG (CN)
SHEN YIJUN (CN)
WU JINGSONG (CN)
CAO FENG (CN)
WANG ZHENG (CN)
TAN JINGWEI (CN)
WU FANG (CN)
XU YAN (CN)
WANG HAIBO (CN)
International Classes:
C07K14/525; A61K38/19; A61P33/00; A61P35/00; C12N15/28
Other References:
GOH C.R. ET AL.: "Aspartic acid 50 and Tyrosine 108 are essential for receptor binding and cytotoxic activity of tumor necrosis factor Beta(lymphotoxin)", PROTEIN ENGINEERING, vol. 4, no. 7, 1991, pages 785 - 791, XP002016899
TOSHIAKI WAKABAYA-SHI ET AL.: "Deletion of Lysine 84 to Lysine 89 Enhances the Cytotoxicity and the Receptor Binding Affinity of Human Lymphotoxin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 13, 1990, pages 7604 - 7609
WANG GUOLI ET AL.: "The Computer Simulation Study on the Interaction Between TNF and its Receptors", CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 14, no. 3, June 1998 (1998-06-01), pages 280 - 288
TOSHIAKI WAKABAYA-SHI ET AL.: "Deletion of Lysine 84 to Lysine 89 Enhances the Cytotoxicity and the Receptor Binding Affinity of Human Lymphotoxin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 13, 1990, pages 7604 - 7609
WANG GUOLI ET AL.: "The Computer Simulation Study on the Interaction Between TNF and its Receptors", CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 14, no. 3, June 1998 (1998-06-01), pages 280 - 288
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE (435 Guiping Road, Shanghai 3, CN)
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