Title:
RECOMBINANT BACTERIA FOR PRODUCING DE-EPOXIDIZED EPOTHILONE B AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/017523
Kind Code:
A1
Abstract:
Recombinant sorangium cellulosum for producing de-epoxidized epothilone B by fermentation, insertional inactivation of an epoK gene in an epothilone biosynthetic gene cluster in the recombinant bacteria, and a method for producing de-epoxidized epothilone B using the recombinant bacteria.
Inventors:
TANG LI (CN)
QIU RONGGUO (CN)
QIU RONGGUO (CN)
Application Number:
PCT/CN2021/108266
Publication Date:
January 27, 2022
Filing Date:
July 23, 2021
Export Citation:
Assignee:
BEIJING BIOSTAR PHARMACEUTICALS CO LTD (CN)
CHENGDU BIOSTAR PHARMACEUTICALS LTD (CN)
CHENGDU BIOSTAR PHARMACEUTICALS LTD (CN)
International Classes:
C12N15/74; C12N1/21; C12P17/16; C12R1/01
Domestic Patent References:
| WO2002008440A2 | 2002-01-31 |
Foreign References:
| CN110628802A | 2019-12-31 | |||
| US7138279B2 | 2006-11-21 | |||
| CN1333820A | 2002-01-30 | |||
| CN101323869A | 2008-12-17 | |||
| CN104805149A | 2015-07-29 | |||
| US5843718A | 1998-12-01 | |||
| US6033883A | 2000-03-07 |
Other References:
KERN FREDY, DIER TOBIAS K. F., KHATRI YOGAN, EWEN KERSTIN M., JACQUOT JEAN-PIERRE, VOLMER DIETRICH A., BERNHARDT RITA: "Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative", SCIENTIFIC REPORTS, vol. 5, no. 1, 1 December 2015 (2015-12-01), XP055888234, DOI: 10.1038/srep14881
HARDT ET AL., J NAT PROD, vol. 64, 2001, pages 847 - 856
TANG ET AL., SCIENCE, vol. 287, pages 640 - 642
JULIENSHAH, AMTIMICROBIAL. AGENT CHEMOTHER., vol. 46, no. 9, 2002, pages 2772 - 2778
JAONA ET AL., PLASMID, vol. 28, 1992, pages 157 - 165
See also references of EP 4063509A4
HARDT ET AL., J NAT PROD, vol. 64, 2001, pages 847 - 856
TANG ET AL., SCIENCE, vol. 287, pages 640 - 642
JULIENSHAH, AMTIMICROBIAL. AGENT CHEMOTHER., vol. 46, no. 9, 2002, pages 2772 - 2778
JAONA ET AL., PLASMID, vol. 28, 1992, pages 157 - 165
See also references of EP 4063509A4
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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