RECOMBINANT FUSION PROTEIN TARGETING CD40 AND CD47

Title:

RECOMBINANT FUSION PROTEIN TARGETING CD40 AND CD47

Document Type and Number:

WIPO Patent Application WO/2023/213290

Kind Code:

A1

Abstract:

Provided is a recombinant fusion protein comprising (a) an anti-CD40 antibody or an antigen binding portion thereof comprising a heavy chain variable region and a light chain variable region, and (b) a CD47 binding domain. Provided is a nucleic acid molecule encoding the recombinant fusion protein, a vector comprising said nucleic acid and a host cell transformed or transfected with said vector or with such a nucleic acid. Furthermore, provided is a process for the production of said recombinant fusion protein, a medical use of said recombinant fusion protein and a kit comprising said recombinant fusion protein.

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Inventors:

CHEN MINGJIU (CN)
MA MARK ZHIQING (CN)
WANG YUJIE (CN)
XU JINGJING (CN)

Application Number:

PCT/CN2023/092215

Publication Date:

November 09, 2023

Filing Date:

May 05, 2023

Export Citation:

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Assignee:

BIOSION INC (CN)
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)

International Classes:

C07K14/00; A61P35/00; C07K14/435; C07K19/00

Domestic Patent References:

WO2022061124A1	2022-03-24
WO2021197335A1	2021-10-07
WO2020180811A1	2020-09-10
WO2018233607A1	2018-12-27
WO2016024021A1	2016-02-18

Other References:

DE SILVA SURESH, FROMM GEORGE, SHUPTRINE CASEY W., JOHANNES KELLSEY, PATEL ARPITA, YOO KYUNG JIN, HUANG KAIWEN, SCHREIBER TAYLOR H: "CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity", CANCER IMMUNOLOGY RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 8, no. 2, 1 February 2020 (2020-02-01), US , pages 230 - 245, XP093036989, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-19-0493

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