Title:
RECOMBINANT HEPARAN SULFATES
Document Type and Number:
WIPO Patent Application WO/2023/229537
Kind Code:
A3
Abstract:
There is provided a nucleic acid construct comprising one or more internal ribosome entry site (IRES), one or more gene of interest, and a pair of site-specific recombinase, wherein the gene of interest is a heparan sulfate variant gene, a heparan sulfate modification enzyme gene, and/or a heparan sulfate scaffold protein gene. Also disclosed are a vector, a host cell and / or cell line, recombinant heparan sulfates, methods, kits for use thereof.
Inventors:
YANG YUANSHENG (SG)
COOL SIMON MCKENZIE (SG)
LOH HAN PING (SG)
SMITH RAYMOND ALEXANDER ALFRED (SG)
COOL SIMON MCKENZIE (SG)
LOH HAN PING (SG)
SMITH RAYMOND ALEXANDER ALFRED (SG)
Application Number:
PCT/SG2023/050373
Publication Date:
December 28, 2023
Filing Date:
May 26, 2023
Export Citation:
Assignee:
AGENCY SCIENCE TECH & RES (SG)
International Classes:
C08B37/00; C12N15/11
Domestic Patent References:
| WO2018112434A1 | 2018-06-21 | |||
| WO2021041711A1 | 2021-03-04 |
Other References:
NGUYEN, N.T.B . ET AL.: "Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans", SCIENTIFIC REPORTS, vol. 11, no. 1, 21 June 2021 (2021-06-21), pages 1 - 17, XP093027283, [retrieved on 20231120], DOI: 10.1038/S41598-021-92320-X
Attorney, Agent or Firm:
DONALDSON & BURKINSHAW LLP (SG)
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