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Title:
RECOMBINANT MEASLES VIRUS
Document Type and Number:
WIPO Patent Application WO/2022/195900
Kind Code:
A1
Abstract:
The present invention provides: a recombinant measles virus useful as a live vaccine against COVID-19; and a vector used for producing the recombinant measles virus. That is, the present invention is a recombinant measles virus in which a gene encoding a protein of corona virus SARS-CoV-2 is inserted between the N gene region and the P gene region in a measles virus gene; the recombinant measles virus in which the protein is the spike protein of SARS-CoV-2 or a partial protein thereof; and DNA in which a gene encoding a protein of SARS-CoV-2 is inserted into the region from the base at position 1686 to the base at position 1694 in the nucleotide sequence represented by SEQ ID NO: 2.

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Inventors:
YONEDA MISAKO (JP)
KAI CHIEKO (JP)
Application Number:
PCT/JP2021/017632
Publication Date:
September 22, 2022
Filing Date:
May 10, 2021
Export Citation:
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Assignee:
UNIV TOKYO (JP)
International Classes:
C12N15/45; A61K39/165; A61K39/215; A61K48/00; A61P37/04; C12N15/50; C12N15/86
Domestic Patent References:
WO2004000876A12003-12-31
Foreign References:
JP2010115154A2010-05-27
JP2010099041A2010-05-06
JP2021041015A2021-03-18
JP2010115154A2010-05-27
JP2010099041A2010-05-06
JP2001275684A2001-10-09
Other References:
DATABASE NUCLEOTIDE [online] 11 May 2020 (2020-05-11), KAI C ET AL.: "Definition: Synthetic construct nucleocapsid protein (N), phosphoprotein (P/V/C), V protein (P/V/C), C protein (P/V/C), matrix protein (M), fusion protein (F), hemagglutinin protein (H), and large protein (L) genes, complete cds", XP093003706, retrieved from GENBANK Database accession no. MT409882
LU MIJIA, ET AL.: "A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 118, no. 12, 23 March 2021 (2021-03-23), XP055971591, ISSN: 0027-8424, DOI: 10.1073/pnas.2026153118
ROTA ET AL., VIRUS RESEARCH, vol. 31, no. 3, 1994, pages 317 - 330
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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