Title:
RECOMBINANT MICROORGANISM IN WHICH EXPRESSION OF NADH:QUINONE OXIDOREDUCTASE IS CONTROLLED, AND METHOD FOR PRODUCING O-PHOSPHOSERINE, CYSTEINE, AND DERIVATIVE THEREOF BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/270857
Kind Code:
A1
Abstract:
The present application relates to a recombinant microorganism in which the expression of NADH:quinone oxidoreductase is controlled, and a method for producing O-phosphoserine, cysteine, and a derivative of cysteine by using same.
Inventors:
JUNG HWI-MIN (KR)
PARK HYE MIN (KR)
SIM HEE-JIN (KR)
LEE JIN NAM (KR)
PARK HYE MIN (KR)
SIM HEE-JIN (KR)
LEE JIN NAM (KR)
Application Number:
PCT/KR2022/008745
Publication Date:
December 29, 2022
Filing Date:
June 21, 2022
Export Citation:
Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C12N15/70; C12N9/02; C12N9/10; C12P13/06; C12P13/12
Foreign References:
| KR101381048B1 | 2014-04-14 | |||
| KR101694632B1 | 2017-01-10 | |||
| US20050124049A1 | 2005-06-09 | |||
| EP0885962B1 | 2005-04-13 | |||
| US20120190081A1 | 2012-07-26 | |||
| US20120190081A1 | 2012-07-26 | |||
| US7662943B2 | 2010-02-16 | |||
| KR101381048B1 | 2014-04-14 | |||
| US9127324B2 | 2015-09-08 | |||
| US20200048619A1 | 2020-02-13 | |||
| US10323262B2 | 2019-06-18 | |||
| US20170247727A1 | 2017-08-31 |
Other References:
SPEHR VOLKER, SCHLITT ANGELA, SCHEIDE DIERK, GUÉNEBAUT VINCENT, FRIEDRICH THORSTEN: "Overexpression of the Escherichia coli nuo -Operon and Isolation of the Overproduced NADH:Ubiquinone Oxidoreductase (Complex I)", BIOCHEMISTRY, vol. 38, no. 49, 1 December 1999 (1999-12-01), pages 16261 - 16267, XP093017273, ISSN: 0006-2960, DOI: 10.1021/bi9919605
WESTROP G D, GOODALL G, MOTTRAM JC, COOMBS G H: "Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 281, no. 35, 1 September 2006 (2006-09-01), US , pages 25062 - 25075, XP002741273, ISSN: 0021-9258, DOI: 10.1074/jbc.M600688200
WADA, M.TAKAGI, H., APPL. MICROBIOL. BIOCHEM., vol. 73, 2006, pages 48 - 54
KARLINALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
F. M. AUSUBEL ET AL., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY
AHMED ZAHOOR, COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 3, October 2012 (2012-10-01)
WENDISCH V. F. ET AL., CURR OPIN MICROBIOL, vol. 9, no. 3, June 2006 (2006-06-01), pages 268 - 74
PETERS-WENDISCH P. ET AL., APPL ENVIRON MICROBIOL, vol. 7 1, no. II, November 2005 (2005-11-01), pages 139 - 44
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL., MOLECULAR CLONING, 2012
NAKASHIMA N ET AL.: "Bacterial cellular engineering by genome editing and gene silencing", INT J MOL SCI., vol. 15, no. 2, 2014, pages 2773 - 2793, XP055376889, DOI: 10.3390/ijms15022773
WEINTRAUB, H. ET AL.: "Antisense-RNA as a molecular tool for genetic analysis", REVIEWS - TRENDS IN GENETICS, vol. 1, no. 1, 1986
MINO K.ISHIKAWA K., FEBS LETTERS, vol. 551, 2003, pages 133 - 138
BURNS K. E. ET AL., J. AM. CHEM. SOC., vol. 127, 2005, pages 11602 - 11603
APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541 - 545
WESTROP G D, GOODALL G, MOTTRAM JC, COOMBS G H: "Cysteine biosynthesis in Trichomonas vaginalis involves cysteine synthase utilizing O-phosphoserine.", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 281, no. 35, 1 September 2006 (2006-09-01), US , pages 25062 - 25075, XP002741273, ISSN: 0021-9258, DOI: 10.1074/jbc.M600688200
WADA, M.TAKAGI, H., APPL. MICROBIOL. BIOCHEM., vol. 73, 2006, pages 48 - 54
KARLINALTSCHUL, PRO. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873
METHODS ENZYMOL., vol. 183, 1990, pages 63
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
F. M. AUSUBEL ET AL., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY
AHMED ZAHOOR, COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, vol. 3, October 2012 (2012-10-01)
WENDISCH V. F. ET AL., CURR OPIN MICROBIOL, vol. 9, no. 3, June 2006 (2006-06-01), pages 268 - 74
PETERS-WENDISCH P. ET AL., APPL ENVIRON MICROBIOL, vol. 7 1, no. II, November 2005 (2005-11-01), pages 139 - 44
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL., MOLECULAR CLONING, 2012
NAKASHIMA N ET AL.: "Bacterial cellular engineering by genome editing and gene silencing", INT J MOL SCI., vol. 15, no. 2, 2014, pages 2773 - 2793, XP055376889, DOI: 10.3390/ijms15022773
WEINTRAUB, H. ET AL.: "Antisense-RNA as a molecular tool for genetic analysis", REVIEWS - TRENDS IN GENETICS, vol. 1, no. 1, 1986
MINO K.ISHIKAWA K., FEBS LETTERS, vol. 551, 2003, pages 133 - 138
BURNS K. E. ET AL., J. AM. CHEM. SOC., vol. 127, 2005, pages 11602 - 11603
APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541 - 545
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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