Title:
RECOMBINANT MUMPS VIRUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2012/116253
Kind Code:
A3
Abstract:
The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/us/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to MuVIowa/us/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuVΔSH) and/or incapable of expressing the V protein (rMuVΔV).
Inventors:
HE BIAO (US)
Application Number:
PCT/US2012/026436
Publication Date:
February 28, 2013
Filing Date:
February 24, 2012
Export Citation:
Assignee:
UNIV GEORGIA (US)
HE BIAO (US)
HE BIAO (US)
International Classes:
A61K38/08; A61K48/00; A61P31/00; A61P31/12; A61K39/00
Foreign References:
| US20070253972A1 | 2007-11-01 |
Other References:
WILSON, R. L. ET AL.: "Function of small hydrophobic proteins of paramyxovirus", J. VIROL., vol. 80, no. 4, February 2006 (2006-02-01), pages 1700 - 1709, XP055120556
PURI, M. ET AL.: "A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting", J. VIROL., vol. 83, no. 13, July 2009 (2009-07-01), pages 6347 - 6356, XP055120558
XU, P. ET AL.: "Rescue of wild-type mumps virus from a strain associated with recent outbreaks helps to define the role of the SH ORF in the pathogenes is of mumps virus", VIROLOGY, vol. 417, no. 1, 15 August 2011 (2011-08-15), pages 126 - 136, XP028252086
XU, P. ET AL.: "The V protein of mumps virus plays a critical role in pathogenesis", J. VIROL., vol. 86, no. 3, 16 November 2011 (2011-11-16), pages 1768 - 1776, XP055120559
PURI, M. ET AL.: "A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting", J. VIROL., vol. 83, no. 13, July 2009 (2009-07-01), pages 6347 - 6356, XP055120558
XU, P. ET AL.: "Rescue of wild-type mumps virus from a strain associated with recent outbreaks helps to define the role of the SH ORF in the pathogenes is of mumps virus", VIROLOGY, vol. 417, no. 1, 15 August 2011 (2011-08-15), pages 126 - 136, XP028252086
XU, P. ET AL.: "The V protein of mumps virus plays a critical role in pathogenesis", J. VIROL., vol. 86, no. 3, 16 November 2011 (2011-11-16), pages 1768 - 1776, XP055120559
Attorney, Agent or Firm:
JOHNSON, Nancy, A. (Raasch & Gebhardt P.A.,P.O.box 58133, Minneapolis MN, US)
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