Title:
RECOMBINANT NARBONOLIDE POLYKETIDE SYNTHASE
Document Type and Number:
WIPO Patent Application WO2002097062
Kind Code:
A3
Abstract:
Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
Inventors:
ASHLEY GARY (US)
BETLACH MELANIE C (US)
BETLACH MARY (US)
MCDANIEL ROBERT (US)
TANG LI (US)
BETLACH MELANIE C (US)
BETLACH MARY (US)
MCDANIEL ROBERT (US)
TANG LI (US)
Application Number:
PCT/US2002/005642
Publication Date:
July 14, 2005
Filing Date:
February 22, 2002
Export Citation:
Assignee:
KOSAN BIOSCIENCES INC (US)
ASHLEY GARY (US)
BETLACH MELANIE C (US)
BETLACH MARY (US)
MCDANIEL ROBERT (US)
TANG LI (US)
ASHLEY GARY (US)
BETLACH MELANIE C (US)
BETLACH MARY (US)
MCDANIEL ROBERT (US)
TANG LI (US)
International Classes:
C07D323/00; C07H17/08; C12N1/21; C12N9/14; C12N15/52; C12N15/65; C12P17/08; C12P19/62; C07B61/00; (IPC1-7): C12N1/20; C07H21/04; C12N15/00
Foreign References:
| US6265202B1 | 2001-07-24 | |||
| US6117659A | 2000-09-12 | |||
| US5712146A | 1998-01-27 | |||
| US5824513A | 1998-10-20 |
Other References:
XUE ET AL: "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae:Architecture of metabolic diversity", PROC NATL ACAD SCI, vol. 95, October 1998 (1998-10-01), pages 12111 - 12116, XP002117399
XUE ET AL: "Genetic architecture of the polyketide synthase fro methymycim and pikromycin series marcolides", GENE, vol. 245, no. 1, 7 March 2000 (2000-03-07), pages 203 - 211, XP004202977
CHEN ET AL: "The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide", GENE, vol. 263, no. 1-2, 24 January 2001 (2001-01-24), pages 255 - 264
XUE ET AL: "Alternative modular polyketide synthase expression controls macrolactone structure", NATURE, vol. 403, 3 February 2000 (2000-02-03), pages 571 - 575
CHEN ET AL: "mechanism of molecular recognition in the picromycin polyketide synthase", CHEM BIOL, vol. 7, no. 12, December 2000 (2000-12-01), pages 907 - 918
XUE ET AL: "Genetic architecture of the polyketide synthase fro methymycim and pikromycin series marcolides", GENE, vol. 245, no. 1, 7 March 2000 (2000-03-07), pages 203 - 211, XP004202977
CHEN ET AL: "The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide", GENE, vol. 263, no. 1-2, 24 January 2001 (2001-01-24), pages 255 - 264
XUE ET AL: "Alternative modular polyketide synthase expression controls macrolactone structure", NATURE, vol. 403, 3 February 2000 (2000-02-03), pages 571 - 575
CHEN ET AL: "mechanism of molecular recognition in the picromycin polyketide synthase", CHEM BIOL, vol. 7, no. 12, December 2000 (2000-12-01), pages 907 - 918
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