Title:
RECOMBINANT PHAGE AND BACTERIAL DETECTION METHODS
Document Type and Number:
WIPO Patent Application WO/2014/160818
Kind Code:
A3
Abstract:
Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.
Inventors:
KOERIS MICHAEL SANDOR (US)
SHIVERS ROBERT PATRICK (US)
BROWNELL DANIEL ROBERT (US)
HOLDER JASON WYATT (US)
BOWERS JAYSON LINN (US)
SHIVERS ROBERT PATRICK (US)
BROWNELL DANIEL ROBERT (US)
HOLDER JASON WYATT (US)
BOWERS JAYSON LINN (US)
Application Number:
PCT/US2014/031931
Publication Date:
November 20, 2014
Filing Date:
March 27, 2014
Export Citation:
Assignee:
SAMPLE TECHNOLOGIES INC (US)
International Classes:
C12Q1/04
Domestic Patent References:
| WO2012061529A1 | 2012-05-10 | |||
| WO2010010192A1 | 2010-01-28 |
Foreign References:
| US20050175594A1 | 2005-08-11 | |||
| US20120009574A1 | 2012-01-12 |
Other References:
NIGHTINGALE ET AL.: "Combined sigB allelic typing and multiplex PCR provide improved discriminatory power and reliability for Listeria monocytogenes molecular serotyping", J MICROBIOL METHODS, vol. 68, no. 1, 1 January 2006 (2006-01-01), pages 52 - 59, XP022731901, DOI: 10.1016/J.MIMET.2006.06.00
HO ET AL.: "Longitudinal monitoring of Listeria monocytogenes contamination patterns in a farmstead dairy processing facility", J DAIRY SCI., vol. 90, no. 5, 1 May 2007 (2007-05-01), pages 2517 - 2524, XP026955918
DORSCHT ET AL.: "Comparative genome analysis of Listeria bacteriophages reveals extensive mosaicism, programmed translational frameshifting, and a novel prophage insertion site", J BACTERIOL., vol. 191, no. 23, 1 December 2009 (2009-12-01) - 25 September 2009 (2009-09-25), pages 7206 - 7215, XP055293353, DOI: 10.1128/JB.01041-09
HO ET AL.: "Longitudinal monitoring of Listeria monocytogenes contamination patterns in a farmstead dairy processing facility", J DAIRY SCI., vol. 90, no. 5, 1 May 2007 (2007-05-01), pages 2517 - 2524, XP026955918
DORSCHT ET AL.: "Comparative genome analysis of Listeria bacteriophages reveals extensive mosaicism, programmed translational frameshifting, and a novel prophage insertion site", J BACTERIOL., vol. 191, no. 23, 1 December 2009 (2009-12-01) - 25 September 2009 (2009-09-25), pages 7206 - 7215, XP055293353, DOI: 10.1128/JB.01041-09
Attorney, Agent or Firm:
PAVAO, Matthew et al. (1299 Pennsylvania Avenue NW,Suite 70, Washington D.C., US)
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