Title:
RECOMBINANT VECTOR FOR IMPROVING EXPRESSION OF PROTEIN OF INTEREST VIA SUPPRESSION OF INTRACELLULAR IMMUNE RESPONSE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/270946
Kind Code:
A1
Abstract:
The present invention relates to a recombinant vector for improving the expression of a protein of interest, the recombinant vector comprising a first gene construct containing a gene encoding a material for blocking or suppressing the activation of the stimulator of interferon genes (STING) pathway in host cells, thereby improving the expression of a protein of interest via the suppression of STING pathway activation in the host cells, and improving the survival rate of the host cells.
Inventors:
KIM TAE-DON (KR)
LEE SOOYUN (KR)
KONG LINGZU (KR)
LEE SOOYUN (KR)
KONG LINGZU (KR)
Application Number:
PCT/KR2022/008954
Publication Date:
December 29, 2022
Filing Date:
June 23, 2022
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C12N15/85; A61K35/17; A61K48/00; C12N5/0783; C12N9/12
Domestic Patent References:
| WO2019035901A1 | 2019-02-21 |
Foreign References:
| KR20170053500A | 2017-05-16 | |||
| KR20190123257A | 2019-10-31 | |||
| KR20100044855A | 2010-04-30 |
Other References:
FU YAJUAN, FANG YIJUN, LIN ZHANG, YANG LEI, ZHENG LIQUN, HU HAO, YU TINGTING, HUANG BAOTING, CHEN SUXING, WANG HANZE, XU SHAN, BAO: "Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression", ISCIENCE, CELL PRESS, US, vol. 23, no. 4, 24 April 2020 (2020-04-24), US , pages 101026 - 38, XP093016683, ISSN: 2589-0042, DOI: 10.1016/j.isci.2020.101026
Attorney, Agent or Firm:
BAE, KIM & LEE IP (KR)
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