Title:
RECOMBINANT VIRUS CONTAINING DEGRON, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016336
Kind Code:
A1
Abstract:
A recombinant virus containing a degron, a preparation method therefor, and an application thereof. At least one viral protein of the recombinant virus containing the degron contains at least one degron capable of being recognized by a protein degradation system of a host cell, wherein the degron comprises any one of or a combination of at least two of an amino acid sequence, a polypeptide, or a structural motif. Further provided are a nucleic acid molecule, a recombinant vector, a preparation method for the recombinant virus containing the degron, a preparation system for the recombinant virus containing the degron, a vaccine, an oncolytic virus, and a drug. The recombinant virus containing the degron can be recognized and degraded by the protein degradation system in the host cell, the replication capability is weakened or even removed, and after a corresponding vaccine, oncolytic virus or drug is prepared, a good effect and practical application value are achieved.
Inventors:
SI LONGLONG (CN)
Application Number:
PCT/CN2022/110258
Publication Date:
February 16, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
C12N7/01; A61K39/12; A61P31/12; C07K7/06; C07K7/08; C07K14/00; C12N5/10; C12N15/86; C12N15/867
Domestic Patent References:
| WO2017004022A2 | 2017-01-05 |
Foreign References:
| CN112175914A | 2021-01-05 | |||
| CN110914439A | 2020-03-24 |
Other References:
MONTROSE KRISTOPHER; KRISSANSEN GEOFFREY W.: "Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 453, no. 4, 8 October 2014 (2014-10-08), Amsterdam NL , pages 735 - 740, XP029095582, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2014.10.006
SHANSHAN GU; DANRUI CUI; XIAOYU CHEN; XIUFANG XIONG; YONGCHAO ZHAO: "PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery", BIOESSAYS, JOHN WILEY & SONS LTD., GB, vol. 40, no. 4, 23 February 2018 (2018-02-23), GB , pages n/a - n/a, XP071526852, ISSN: 0265-9247, DOI: 10.1002/bies.201700247
QU YU-RONG，ZHAN, YUAN，QIU XU-SHENG，TAN, LEI，SUN YING-JIE，SONG, CUI-PING，MENG, CHAN CHUN，DING: "Influence of the ubiquitin-proteasome system on NDV replication in DF-1 cells", CHINESE VETERINARY SCIENCE, vol. 47, no. 11, 31 December 2017 (2017-12-31), pages 1371 - 1377, XP093034373
LAURA M. LUH; ULRIKE SCHEIB; KATRIN JUENEMANN; LARS WORTMANN; MICHAEL BRANDS; PHILIPP M. CROMM: "Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 59, no. 36, 30 July 2020 (2020-07-30), Hoboken, USA, pages 15448 - 15466, XP072091470, ISSN: 1433-7851, DOI: 10.1002/anie.202004310
SHANSHAN GU; DANRUI CUI; XIAOYU CHEN; XIUFANG XIONG; YONGCHAO ZHAO: "PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery", BIOESSAYS, JOHN WILEY & SONS LTD., GB, vol. 40, no. 4, 23 February 2018 (2018-02-23), GB , pages n/a - n/a, XP071526852, ISSN: 0265-9247, DOI: 10.1002/bies.201700247
QU YU-RONG，ZHAN, YUAN，QIU XU-SHENG，TAN, LEI，SUN YING-JIE，SONG, CUI-PING，MENG, CHAN CHUN，DING: "Influence of the ubiquitin-proteasome system on NDV replication in DF-1 cells", CHINESE VETERINARY SCIENCE, vol. 47, no. 11, 31 December 2017 (2017-12-31), pages 1371 - 1377, XP093034373
LAURA M. LUH; ULRIKE SCHEIB; KATRIN JUENEMANN; LARS WORTMANN; MICHAEL BRANDS; PHILIPP M. CROMM: "Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 59, no. 36, 30 July 2020 (2020-07-30), Hoboken, USA, pages 15448 - 15466, XP072091470, ISSN: 1433-7851, DOI: 10.1002/anie.202004310
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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