Title:
RECONSTITUTION OF EXTRACELLULAR MATRIXES FOR MUSCULOSKELETAL JOINT TISSUE REPAIR USING BIOMIMETIC BIOLOGIC AND SYNTHETIC FACTORS
Document Type and Number:
WIPO Patent Application WO/2022/174071
Kind Code:
A3
Abstract:
The invention features compositions and methods for repairing musculoskeletal defects or injuries using a bioactive scaffold comprising fibrinogen, thrombin, SDF-1 and/or KGN as well as methods of making the scaffold.
Inventors:
JAYASURIYA CHATHURAKA TEEKSHANA (US)
YANG DANIEL S (US)
YANG DANIEL S (US)
Application Number:
PCT/US2022/016171
Publication Date:
November 17, 2022
Filing Date:
February 11, 2022
Export Citation:
Assignee:
RHODE ISLAND HOSPITAL (US)
International Classes:
A61K35/32; A61P19/04; C12N5/077; C12N15/86
Other References:
YANG ZHEN, LI HAO, YUAN ZHIGUO, FU LIWEI, JIANG SHUANGPENG, GAO CANGJIAN, WANG FUXIN, ZHA KANGKANG, TIAN GUANGZHAO, SUN ZHIQIANG, : "Endogenous cell recruitment strategy for articular cartilage regeneration", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 114, 1 September 2020 (2020-09-01), AMSTERDAM, NL, pages 31 - 52, XP093008156, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2020.07.008
SETAYESHMEHR ET AL.: "Chondrogenesis of human adipose-derived mesenchymal stromal cells on the [devitalized costal cartilage matrix/poly(vinyl alcohol)/fibrin] hybrid scaffolds", EUROPEAN POLYMER JOURNA L, vol. 118, 25 April 2019 (2019-04-25), pages 528 - 541, XP085775939, DOI: 10.1016/j.eurpolymj.2019.04.044
SETAYESHMEHR ET AL.: "Chondrogenesis of human adipose-derived mesenchymal stromal cells on the [devitalized costal cartilage matrix/poly(vinyl alcohol)/fibrin] hybrid scaffolds", EUROPEAN POLYMER JOURNA L, vol. 118, 25 April 2019 (2019-04-25), pages 528 - 541, XP085775939, DOI: 10.1016/j.eurpolymj.2019.04.044
Attorney, Agent or Firm:
HOLMANDER, Daniel J. et al. (US)
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