Title:
RED LIGHT-REGULATED TRANSCRIPTIONAL ACTIVATION DEVICE/SYSTEM FOR MAMMALS, AND CONSTRUCTION METHOD THEREFOR AND USE THEREOF IN GENE THERAPY
Document Type and Number:
WIPO Patent Application WO/2023/231931
Kind Code:
A1
Abstract:
Disclosed in the present invention is a red light-regulated transcriptional activation device/system (referred to as an REDLIP device/system) for mammals, which comprises a red light photosensitive protein element, a transcriptional activation element, and an effector element. The REDLIP device/system has the characteristics of a simple structure, small modules, no toxicity or side effects, a rapid response, a high transcriptional activation efficiency, a high spatio-temporal specificity, strong adjustability, etc. The REDLIP device/system can accurately and rapidly activate genetic circuits under the regulation of red light, and has an important application value in various fields such as basic biology and regenerative medicine research. The device/system has small elements and modules and can be delivered by adeno-associated viruses (AAV), thereby achieving accurate, efficient and rapid gene therapy for diseases such as diabetes and obesity. The REDLIP device/system provides an accurate, efficient and controllable tool for gene therapy, and has potential value in the clinical application of gene therapy.
Inventors:
YE HAIFENG (CN)
QIAO LONGLIANG (CN)
NIU LINGXUE (CN)
WANG ZHIHAO (CN)
QIAO LONGLIANG (CN)
NIU LINGXUE (CN)
WANG ZHIHAO (CN)
Application Number:
PCT/CN2023/096653
Publication Date:
December 07, 2023
Filing Date:
May 26, 2023
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
International Classes:
C12N15/864; A61K38/28; A61P35/00
Domestic Patent References:
| WO2013185892A1 | 2013-12-19 |
Foreign References:
| CN113088532A | 2021-07-09 | |||
| CN110468153A | 2019-11-19 | |||
| CN107174655A | 2017-09-19 | |||
| CN102643852A | 2012-08-22 | |||
| CN104812773A | 2015-07-29 |
Other References:
DATABASE Protein 19 May 2021 (2021-05-19), ANONYMOUS : "bacteriophytochrome BphP [Deinococcus radiodurans]", XP093117057, retrieved from NCBI Database accession no. WP_010889310.1
WEI QIYAO, XU CHENCHEN, WANG MEIYAN, YE HAIFENG: "Development and application of optogenetic tools", CHINESE JOURNAL OF BIOTECHNOLOGY, ZHONGGUO KEXUEYUAN WEISHENGWU YANJIUSUO, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF MICROBIOLOGY, CN, vol. 35, no. 12, 25 December 2019 (2019-12-25), CN , pages 2238 - 2256, XP093117060, ISSN: 1000-3061, DOI: 10.13345/j.cjb.190298
WEI QIYAO, XU CHENCHEN, WANG MEIYAN, YE HAIFENG: "Development and application of optogenetic tools", CHINESE JOURNAL OF BIOTECHNOLOGY, ZHONGGUO KEXUEYUAN WEISHENGWU YANJIUSUO, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF MICROBIOLOGY, CN, vol. 35, no. 12, 25 December 2019 (2019-12-25), CN , pages 2238 - 2256, XP093117060, ISSN: 1000-3061, DOI: 10.13345/j.cjb.190298
Attorney, Agent or Firm:
MSJLAW OFFICE et al. (CN)
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