REDUCED FORMATE POLY(ALKYLENE OXIDES) WITH SECONDARY AMINES FOR REDUCING IMPURITY FORMATION

Title:

REDUCED FORMATE POLY(ALKYLENE OXIDES) WITH SECONDARY AMINES FOR REDUCING IMPURITY FORMATION

Document Type and Number:

WIPO Patent Application WO2003092649

Kind Code:

A3

Abstract:

Oral delivery vehicles and compositions for providing sustained release of secondary amines including reboxetine with reduced formate poly(alkylene oxide) polymers are provided. Processes for reducing the amount of the formic compounds from the polymers comprising contacting the polymers with an acid having a Pka lower than that of formic acid are also disclosed.

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Inventors:

SEROFF SYLVIA L
YAM NOYMI V
AYER ATUL D
LAM ANDREW C

Application Number:

PCT/US2003/013156

Publication Date:

January 22, 2004

Filing Date:

April 28, 2003

Export Citation:

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Assignee:

ALZA CORP C O JOHNSON & JOHNSO (US)

International Classes:

A61K9/00; A61K9/22; A61K9/24; A61K31/5375; A61K31/765; A61K47/34; A61K9/20; (IPC1-7): A61K9/00; A61K47/34; A61K31/765

Domestic Patent References:

WO2002088217A1	2002-11-07
WO2001019337A2	2001-03-22

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