Title:
REGENERATION OF RETINAL GANGLION CELLS
Document Type and Number:
WIPO Patent Application WO/2021/143827
Kind Code:
A1
Abstract:
Provided herein are compositions and methods for regenerating retinal ganglion cells (RGCs) from retinal neuron cells by activating transcription factors such as one or more of Atoh7, Brn3B, Sox4, Sox11, or Ils1. The retinal neuron cells may be interneuron cells such as amacrine cells, horizontal cells, and bipolar cell. The regenerated RGCs can project axons into discrete subcortical brain regions and establish retina-brain connections. They can respond to visual stimulation and transmit electrical signals into the brain. Therefore, the regenerated RGCs can replace damaged or degenerated RGCs, thereby treating vision impairment or blindness. The methods are likewise applicable to degenerated, damaged, or aged RGCs to stimulate them to regrow functional axons, thereby rejuvenating these RGCs.
Inventors:
LIU HONGJUN (CN)
WEI XIAOHU (CN)
QIAO NA (CN)
WEI XIAOHU (CN)
QIAO NA (CN)
Application Number:
PCT/CN2021/072108
Publication Date:
July 22, 2021
Filing Date:
January 15, 2021
Export Citation:
Assignee:
UNIV SHANGHAI TECHNOLOGY (CN)
International Classes:
C12N15/86; A61K48/00; A61P27/02; A61P27/06; C12N5/10; C12N15/85
Domestic Patent References:
| WO2012061045A2 | 2012-05-10 | |||
| WO2017176810A1 | 2017-10-12 |
Foreign References:
| CN110302398A | 2019-10-08 | |||
| CN110305846A | 2019-10-08 |
Other References:
JIANG YING; DING QIAN; XIE XIAOLING; LIBBY RICHARD T; LEFEBVRE VERONIQUE; GAN LIN: "Transcription Factors SOX4 and SOX11 Function Redundantly to Regulate the Development of Mouse Retinal Ganglion Cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 25, 21 June 2013 (2013-06-21), pages 18429 - 18438, XP055830028, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.478503
WU WEI-LIN;LIU JIN-RONG;ZHONG JIA-NING;WANG HUI: "The protective effect of Brn3b gene on retinal ganglion cells in the condition of optic nerve injury", RECENT ADVANCES IN OPHTHALMOLOGY, vol. 38, no. 9, 31 August 2018 (2018-08-31), pages 815 - 820, XP055830029, ISSN: 1003-5141, DOI: 10.13389/j.cnki.rao.2018.0193
See also references of EP 4090751A4
WU WEI-LIN;LIU JIN-RONG;ZHONG JIA-NING;WANG HUI: "The protective effect of Brn3b gene on retinal ganglion cells in the condition of optic nerve injury", RECENT ADVANCES IN OPHTHALMOLOGY, vol. 38, no. 9, 31 August 2018 (2018-08-31), pages 815 - 820, XP055830029, ISSN: 1003-5141, DOI: 10.13389/j.cnki.rao.2018.0193
See also references of EP 4090751A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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