Title:
REGULATION OF MACROPHAGE ACTIVATION USING MIR - 125B
Document Type and Number:
WIPO Patent Application WO/2012/177565
Kind Code:
A3
Abstract:
The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125b or anti-miR-125b oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.
Inventors:
CHAUDHURI AADEL (US)
SO ALEX STEVEN (US)
BALTIMORE DAVID (US)
O'CONNELL RYAN M (US)
SO ALEX STEVEN (US)
BALTIMORE DAVID (US)
O'CONNELL RYAN M (US)
Application Number:
PCT/US2012/043010
Publication Date:
February 28, 2013
Filing Date:
June 18, 2012
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
CHAUDHURI AADEL (US)
SO ALEX STEVEN (US)
BALTIMORE DAVID (US)
O'CONNELL RYAN M (US)
CHAUDHURI AADEL (US)
SO ALEX STEVEN (US)
BALTIMORE DAVID (US)
O'CONNELL RYAN M (US)
International Classes:
A61K31/7088; C12N15/113
Domestic Patent References:
| WO2011017030A2 | 2011-02-10 |
Foreign References:
| US20080261908A1 | 2008-10-23 | |||
| US20050261218A1 | 2005-11-24 |
Other References:
TILI ET AL.: "Modulation of miR-155 and miR-125b Levels following LipopolysaccharidefTNF- .alpha. Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock", J. IMMUNOL., vol. 179, 2007, pages 5082 - 5089
Attorney, Agent or Firm:
DELANEY, Karoline, A. (Martens Olson & Bear, LLP,2040 Main Street, 14th Floo, Irvine CA, US)
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