Title:
REGULATORS OF TYPE-1 TUMOR NECROSIS FACTOR RECEPTOR AND OTHER CYTOKINE RECEPTOR SHEDDING
Document Type and Number:
WIPO Patent Application WO2001064856
Kind Code:
A3
Abstract:
The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of ectodomain shedding. In preferred embodiments, methods and compositions for the regulation of TNF Type-1 Receptor ectodomain shedding are provided. The present invention finds use in therapeutics, diagnostics, and drug screening applications.
Inventors:
LEVINE STEWART (US)
Application Number:
PCT/US2001/006464
Publication Date:
April 18, 2002
Filing Date:
February 28, 2001
Export Citation:
Assignee:
US HEALTH (US)
LEVINE STEWART (US)
LEVINE STEWART (US)
International Classes:
C07H21/04; C07K14/715; C07K16/40; C12N9/64; C12N15/113; C12N15/57; C12Q1/68; C12Q1/6883; A61K38/00; A61K39/00; A61K48/00; (IPC1-7): C12N9/64; C12N5/10; C12N15/57; C07K16/40; A61K48/00; C12Q1/68; G01N33/573; G01N33/50; C12Q1/37; C12N1/21
Domestic Patent References:
| WO1999063088A2 | 1999-12-09 | |||
| WO1998020140A1 | 1998-05-14 | |||
| WO1999058559A2 | 1999-11-18 | |||
| WO2000032221A2 | 2000-06-08 | |||
| WO2000073454A1 | 2000-12-07 | |||
| WO2000075375A1 | 2000-12-14 |
Foreign References:
| EP0657536A1 | 1995-06-14 | |||
| DE1243204B | 1967-06-29 |
Other References:
DATABASE EM_HUM [online] EMBL; 16 February 2000 (2000-02-16), CUI, X. ET AL.: "Identification of an aminopeptidase regulator of Type I Tumor Necrosis Factor Recdeptor shedding", XP002181506, retrieved from EBI accession no. AF222340 Database accession no. AF222340
HATTORI AKIRA ET AL: "Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 125, no. 5, May 1999 (1999-05-01), pages 931 - 938, XP002155174, ISSN: 0021-924X
LEVINE STEWART J ET AL: "Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 12, no. 2, 1995, pages 196 - 204, XP000926691, ISSN: 1044-1549
HATTORI AKIRA ET AL: "Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 125, no. 5, May 1999 (1999-05-01), pages 931 - 938, XP002155174, ISSN: 0021-924X
LEVINE STEWART J ET AL: "Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 12, no. 2, 1995, pages 196 - 204, XP000926691, ISSN: 1044-1549
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