Title:
REMEDIAL AGENT FOR ANXIETY NEUROSIS OR DEPRESSION AND PIPERAZINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2002/000259
Kind Code:
A1
Abstract:
A remedy for anxiety neurosis or depression which contains an MC¿4? receptor antagonist as the active ingredient; and a piperazine derivative represented by the formula [1] or a pharmaceutically acceptable salt thereof, wherein Ar?1¿ represents (un)substituted phenyl, etc.; Ar?2¿ represents (un)substituted naphthyl, quinolyl, a group represented by the formula [a] (wherein R?4¿ is hydrogen or halogeno; and X-Y is CH-NH, CH-O, CH-S, or N-O), or a group represented by the formula [b] (wherein R?5¿ is hydrogen, hydroxy, or C¿1-10? alkoxy); R?1¿ represents hydrogen, C¿1-10? alkyl, etc.; R?2¿ and R?3¿ are the same or different and each is hydrogen or C¿1-10? alkyl; A-B represents N-CH¿2?, CH-CH¿2?, C(OH)-CH¿2?, or C=CH; T?1¿ represents a single bond, -O-, etc.; and n is an integer of 1 to 10.
More Like This:
| JP2014098004 | INTRACELLULAR KINASE INHIBITORS |
| WO/1997/018215 | ANALOGUES OF N-ACETYLARDEEMIN, METHOD OF PREPARATION AND USES THEREOF |
Inventors:
NAKAZATO ATSURO (JP)
CHAKI SHIGEYUKI (JP)
OKUBO TAKETOSHI (JP)
OGAWA SHIN-ICHI (JP)
ISHII TAKAAKI (JP)
CHAKI SHIGEYUKI (JP)
OKUBO TAKETOSHI (JP)
OGAWA SHIN-ICHI (JP)
ISHII TAKAAKI (JP)
Application Number:
PCT/JP2001/005524
Publication Date:
January 03, 2002
Filing Date:
June 27, 2001
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
NAKAZATO ATSURO (JP)
CHAKI SHIGEYUKI (JP)
OKUBO TAKETOSHI (JP)
OGAWA SHIN ICHI (JP)
ISHII TAKAAKI (JP)
NAKAZATO ATSURO (JP)
CHAKI SHIGEYUKI (JP)
OKUBO TAKETOSHI (JP)
OGAWA SHIN ICHI (JP)
ISHII TAKAAKI (JP)
International Classes:
A61K31/495; A61K31/496; A61K45/06; A61P25/22; A61P25/24; C07D295/125; (IPC1-7): A61K45/00; A61K31/496; A61K31/495; A61P25/24; A61P25/22; C07D295/12; C07D239/42; C07D215/12; C07D307/81; C07D209/14; C07D333/20; C07D311/80; C07D261/20; C07D211/44; C07D211/70; C07D295/06; C07D295/02; C07D295/08; C07D295/14; C07D211/20; C07D211/22
Domestic Patent References:
| WO1993014076A1 | 1993-07-22 | |||
| WO1998037097A1 | 1998-08-27 |
Foreign References:
| JPH0641071A | 1994-02-15 | |||
| EP0479546A2 | 1992-04-08 |
Other References:
VEDJELEK Z. ET AL.: "Potential antitussives: synthesis and pharmacology of a series of 1-(2-amino-2-(4-fluorophenyl)ethyl)-4-(2-benzoylpropyl)piperazines", COLLECT. CZECH. CHEM. COMMUN., vol. 48, no. 10, 1983, pages 2977 - 2988, XP002946958
KASK A. ET AL.: "Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo", ENDOCRINOLOGY, vol. 139, no. 12, 1998, pages 5006 - 5014, XP002946959
See also references of EP 1295608A4
KASK A. ET AL.: "Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo", ENDOCRINOLOGY, vol. 139, no. 12, 1998, pages 5006 - 5014, XP002946959
See also references of EP 1295608A4
Attorney, Agent or Firm:
Kitagawa, Tomizo (LTD. Patent Division 24-1 Takata 3-chome Toshima-ku, Tokyo, JP)
Download PDF:
Previous Patent: MEDICINAL COMPOSITIONS FOR ANGIOGENIC THERAPY
Next Patent: SURFACTANT-CONTAINING FORMULATIONS FOR EXTENDED RELEASE OF SOMATOTROPIN
Next Patent: SURFACTANT-CONTAINING FORMULATIONS FOR EXTENDED RELEASE OF SOMATOTROPIN