Title:
REMEDIES FOR DRUG ADDICTION
Document Type and Number:
WIPO Patent Application WO/1999/011289
Kind Code:
A1
Abstract:
Remedies for drug addiction which contain as the active ingredient $g(k)-opioid receptor agonists typified by the compounds represented by general formula (I). These $g(k)-opioid receptor agonists are useful as remedies for drug addiction which are reduced in side effects and act on the reward effect expression mechanism so as to inhibit the expression of mental addiction and physical addiction simultaneously, different from the symptomatic therapy conventionally employed in treating drug addiction.
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Inventors:
NAGASE HIROSHI (JP)
ENDOH TAKASHI (JP)
SUZUKI TSUTOMU (JP)
KAWAMURA KUNIAKI (JP)
OSHIMA KOJI (JP)
INADA HIDEAKI (JP)
ENDOH TAKASHI (JP)
SUZUKI TSUTOMU (JP)
KAWAMURA KUNIAKI (JP)
OSHIMA KOJI (JP)
INADA HIDEAKI (JP)
Application Number:
PCT/JP1998/003937
Publication Date:
March 11, 1999
Filing Date:
September 02, 1998
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
NAGASE HIROSHI (JP)
ENDOH TAKASHI (JP)
SUZUKI TSUTOMU (JP)
KAWAMURA KUNIAKI (JP)
OSHIMA KOJI (JP)
INADA HIDEAKI (JP)
NAGASE HIROSHI (JP)
ENDOH TAKASHI (JP)
SUZUKI TSUTOMU (JP)
KAWAMURA KUNIAKI (JP)
OSHIMA KOJI (JP)
INADA HIDEAKI (JP)
International Classes:
A61K31/485; C07D489/08; (IPC1-7): A61K45/00; A61K31/47
Domestic Patent References:
| WO1993015081A1 | 1993-08-05 |
Other References:
KUZUMIN ALEXANDER V. et al., "kappa-Opioid Receptor Agonist U50, 488H Modulates Cocaine and Morphine Self-Administration in Drug-Naive Rats and Mice", EUROPEAN JOURNAL OF PHARMACOLOGY, March 1997, Vol. 321, No. 3, pp. 265-271.
SHIPPENBERG T.S. et al., "kappa-Opioid Receptor Agonist Prevent Sensitization to the Conditioned Rewarding Effects of Cocaine", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1996, Vol. 276, No. 2, pp. 545-554.
MAISONNEUVE I.M. et al., "U50, 488, a kappa Opioid Receptor Agonist, Attenuates Cocaine-Induced Increases in Extracellular Dopamine in the Nucleus Accumbens of Rats", NEUROSCIENCE LETTERS, 1994, Vol. 181, No. 1-2, pp. 57-60.
HEIDBREDER Ch.A. et al., "The kappa-Opioid Receptor Agonist U-69593 Attenuates Cocaine-induced Behavioral Sensitization in the Rat", BRAIN RESEARCH, 1993, Vol. 616, No. 1-2, pp. 335-8.
TSUTOMU SUZUKI et al., "Opioid Receptor Type and Dependency (in Japanese)", FOLIA PHARMACOLOGICA JAPONICA, April 1997, Vol. 109, No. 4, pages 165-173.
FUNADA M. et al., "Blockade of Morphine Reward Through the Activation of kappa-Opioid Receptors in Mice", NEUROPHARMACOLOGY, 1993, Vol. 32, No. 12, pp. 1315-1323.
TSUTOMU SUZUKI et al., "Mechanism of Development of Drug Dependency (in Japanese)", MOLECULAR MEDICINE, 1995, Vol. 32, No. 2, pp. 140-145.
DI CHIARA CAETANO et al., "Drugs Abused by Humans Preferentially Increase Synaptic Dopamine Concentrations in the Mesolimbic System of Freely Moving Rats", PROC. NATL. ACAD. SCI. USA, 1988, Vol. 85, No. 12, pp. 5274-5278.
See also references of EP 0974363A4
SHIPPENBERG T.S. et al., "kappa-Opioid Receptor Agonist Prevent Sensitization to the Conditioned Rewarding Effects of Cocaine", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1996, Vol. 276, No. 2, pp. 545-554.
MAISONNEUVE I.M. et al., "U50, 488, a kappa Opioid Receptor Agonist, Attenuates Cocaine-Induced Increases in Extracellular Dopamine in the Nucleus Accumbens of Rats", NEUROSCIENCE LETTERS, 1994, Vol. 181, No. 1-2, pp. 57-60.
HEIDBREDER Ch.A. et al., "The kappa-Opioid Receptor Agonist U-69593 Attenuates Cocaine-induced Behavioral Sensitization in the Rat", BRAIN RESEARCH, 1993, Vol. 616, No. 1-2, pp. 335-8.
TSUTOMU SUZUKI et al., "Opioid Receptor Type and Dependency (in Japanese)", FOLIA PHARMACOLOGICA JAPONICA, April 1997, Vol. 109, No. 4, pages 165-173.
FUNADA M. et al., "Blockade of Morphine Reward Through the Activation of kappa-Opioid Receptors in Mice", NEUROPHARMACOLOGY, 1993, Vol. 32, No. 12, pp. 1315-1323.
TSUTOMU SUZUKI et al., "Mechanism of Development of Drug Dependency (in Japanese)", MOLECULAR MEDICINE, 1995, Vol. 32, No. 2, pp. 140-145.
DI CHIARA CAETANO et al., "Drugs Abused by Humans Preferentially Increase Synaptic Dopamine Concentrations in the Mesolimbic System of Freely Moving Rats", PROC. NATL. ACAD. SCI. USA, 1988, Vol. 85, No. 12, pp. 5274-5278.
See also references of EP 0974363A4
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