Title:
REMEDY FOR HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2005/074928
Kind Code:
A1
Abstract:
It is intended to eliminate the restricted indication in the cases with elevated intracranial pressure in the acute stage of cerebral attack to which nicardipine or its salt has been contraindicated. It is found out for the first time that, in cerebral infarct model rats, nicardipine or its salt would not affect the intracranial pressure, different from the common recognition, even in a group with elevated intracranial pressure in the acute stage of onset. Namely, a remedy for hypertension for patients with elevated intracranial pressure in the acute stage of cerebral attack which contains, as the active ingredient, nicardipine or its salt.
Inventors:
KATAYAMA YOICHI (JP)
SUZUKI MASANORI (JP)
HAYASHI ASUKA (JP)
SUZUKI MASANORI (JP)
HAYASHI ASUKA (JP)
Application Number:
PCT/JP2005/001467
Publication Date:
August 18, 2005
Filing Date:
February 02, 2005
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
UNIV NIHON (JP)
KATAYAMA YOICHI (JP)
SUZUKI MASANORI (JP)
HAYASHI ASUKA (JP)
UNIV NIHON (JP)
KATAYAMA YOICHI (JP)
SUZUKI MASANORI (JP)
HAYASHI ASUKA (JP)
International Classes:
A61K31/4422; A61P9/12; (IPC1-7): A61K31/4422; A61P9/12
Other References:
TAKENAKA T. ET AL: "Cerebrovascular effects of YC-93, a new vasodilator, in dogs, monkeys and human patients", INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY, vol. 17, no. 1, 1979, pages 1 - 11, XP002987945
WELTY T.E. ET AL: "Pathophysiology and treatment of subarachnoid hemorrhage", CLINICAL PHARMACY, vol. 9, no. 1, 1990, pages 35 - 39, XP002987946
WELTY T.E. ET AL: "Pathophysiology and treatment of subarachnoid hemorrhage", CLINICAL PHARMACY, vol. 9, no. 1, 1990, pages 35 - 39, XP002987946
Attorney, Agent or Firm:
Shoji, Takashi (2-10 Iwamotocho 3-chom, Chiyoda-ku Tokyo 32, JP)
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