Title:
REMEDY OR PREVENTIVE FOR DIGESTIVE ULCER
Document Type and Number:
WIPO Patent Application WO/2007/097403
Kind Code:
A1
Abstract:
It is intended to provide a remedy or a preventive for digestive ulcer being efficacious for ulcer in the small intestine, etc., on which the existing gastric antisecretory agents such as proton pump inhibitors exert no effect, and superior in efficaciousness and safety to Allopurinol. A medicinal composition, which contains a non-purine xanthine oxidase inhibitor as the active ingredient, is useful as a remedy or a preventive for ulceration in the digestive tract caused by gastric acid, pepsin, stress, Helicobacter pylori, the attack by NSAID, etc. This medicinal composition is particularly useful as a nonconventional remedy for ulcer because of being efficacious against ulcer in the small intestine on which the existing remedies for gastric and duodenal ulcer inhibiting gastric acid secretion such as proton pump inhibitors exert no effect.
Inventors:
KAWAKAMI MASAKATSU (JP)
KETO YOSHIHIRO (JP)
IKEDA KEN (JP)
FUKUDA MARI (JP)
SATO JUNJI (JP)
KETO YOSHIHIRO (JP)
IKEDA KEN (JP)
FUKUDA MARI (JP)
SATO JUNJI (JP)
Application Number:
PCT/JP2007/053310
Publication Date:
August 30, 2007
Filing Date:
February 22, 2007
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KAWAKAMI MASAKATSU (JP)
KETO YOSHIHIRO (JP)
IKEDA KEN (JP)
FUKUDA MARI (JP)
SATO JUNJI (JP)
KAWAKAMI MASAKATSU (JP)
KETO YOSHIHIRO (JP)
IKEDA KEN (JP)
FUKUDA MARI (JP)
SATO JUNJI (JP)
International Classes:
A61K45/00; A61K31/381; A61K31/4025; A61K31/4155; A61K31/42; A61K31/427; A61K31/44; A61K31/4427; A61K31/4535; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K31/55; A61P1/00; A61P1/04; A61P43/00; C07D213/79; C07D231/14; C07D261/18; C07D277/20; C07D277/56; C07D333/40; C07D401/10; C07D401/12; C07D405/10; C07D405/12; C07D409/10; C07D413/10; C07D417/10; C07D417/12
Domestic Patent References:
| WO1998018765A1 | 1998-05-07 | |||
| WO1992009279A1 | 1992-06-11 | |||
| WO2006022375A1 | 2006-03-02 | |||
| WO2006022374A1 | 2006-03-02 |
Other References:
HUH K. ET AL.: "The effect of rebamipide on gastric xanthine oxidase activity and type conversion in ethanol-treated rats", FREE RADICAL BIOLOGY & MEDICINE, vol. 20, no. 7, 1996, pages 967 - 971, XP003017255
DODO K. ET AL.: "Kyoketsu Saikanryu-Ammonia Fuka Rat no Kyusei Inenmaku Byohen (AGML) no Hassei ni Taisuru Troxipide no Yokusei Koka", FOLIA PHARMACOLOGICA JAPONICA, vol. 104, 1994, pages 313 - 323, XP003017256
BASIVIREDDY J. ET AL.: "Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes", BIOCHEMCAL PHARMACOLOGY, vol. 65, no. 4, 2003, pages 683 - 695, XP003017257
KHOSRAVAN R. ET AL.: "Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 46, no. 8, August 2006 (2006-08-01), pages 855 - 866, XP003017258
GUT, vol. 38, 1996, pages 518 - 524
FEBS LETTERS, vol. 213, no. 1, 1987, pages 23 - 28
NANKO-DO, KONNICHINOCHIRYOYAKU, 2005, pages 86 - 115
DRUGS, vol. 49, no. 1, 1995, pages 51 - 70
DRUGS, vol. 52, no. 5, 1996, pages 13 - 23
DODO K. ET AL.: "Kyoketsu Saikanryu-Ammonia Fuka Rat no Kyusei Inenmaku Byohen (AGML) no Hassei ni Taisuru Troxipide no Yokusei Koka", FOLIA PHARMACOLOGICA JAPONICA, vol. 104, 1994, pages 313 - 323, XP003017256
BASIVIREDDY J. ET AL.: "Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes", BIOCHEMCAL PHARMACOLOGY, vol. 65, no. 4, 2003, pages 683 - 695, XP003017257
KHOSRAVAN R. ET AL.: "Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 46, no. 8, August 2006 (2006-08-01), pages 855 - 866, XP003017258
GUT, vol. 38, 1996, pages 518 - 524
FEBS LETTERS, vol. 213, no. 1, 1987, pages 23 - 28
NANKO-DO, KONNICHINOCHIRYOYAKU, 2005, pages 86 - 115
DRUGS, vol. 49, no. 1, 1995, pages 51 - 70
DRUGS, vol. 52, no. 5, 1996, pages 13 - 23
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (3-11 Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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