Title:
RENAL FUNCTION PROTECTANT
Document Type and Number:
WIPO Patent Application WO/2021/193856
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition containing a citric acid, a pharmaceutically acceptable salt of a citric acid, a hydrate thereof, or a mixture thereof. The administration of this pharmaceutical composition enables a renal function to be protected or a dietary acid load on the kidneys to be alleviated.
Inventors:
ABE MICHIAKI (JP)
KOSHIBA SEIZO (JP)
NISHIOKA KOICHIRO (JP)
YAMASAKI SATOMI (JP)
SAKURAI TETSUYA (JP)
KOSHIBA SEIZO (JP)
NISHIOKA KOICHIRO (JP)
YAMASAKI SATOMI (JP)
SAKURAI TETSUYA (JP)
Application Number:
PCT/JP2021/012668
Publication Date:
September 30, 2021
Filing Date:
March 25, 2021
Export Citation:
Assignee:
UNIV TOHOKU (JP)
NIPPON CHEMIPHAR CO (JP)
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61K31/194; A61K9/20; A61P13/12
Domestic Patent References:
| WO2020080499A1 | 2020-04-23 | |||
| WO2018193648A1 | 2018-10-25 | |||
| WO2018193752A1 | 2018-10-25 |
Foreign References:
| JP2018177752A | 2018-11-15 |
Other References:
KANAUCHI, MASAO: "Paradigm Shift for Indicators and Guidance in Diet Therapy: Dietary Inflammation and Dietary Acid Load", JOURNAL OF CLINICAL PHYSIOLOGY, vol. 49, no. 2, 2019, pages 59 - 63, XP055862018
BRITO-ASHURST, I.D. ET AL.: "Bicarbonate supplementation slows progression of CKD and improves nutritional status", J. AM. SOC. NEPHROL., vol. 20, 2009, pages 2075 - 2084, XP055673749, DOI: 10.1681/ASN.2008111205
SOUMA T. ET AL.: "Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells", J. AM. SOC. NEPHROL., vol. 22, 2011, pages 635 - 648, XP055556938, DOI: 10.1681/ASN.2009111130
JOURNAL OF THE JAPANESE SOCIETY OF NEPHROLOGY, 2012
BRITO-ASHURST, I.D. ET AL.: "Bicarbonate supplementation slows progression of CKD and improves nutritional status", J. AM. SOC. NEPHROL., vol. 20, 2009, pages 2075 - 2084, XP055673749, DOI: 10.1681/ASN.2008111205
SOUMA T. ET AL.: "Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells", J. AM. SOC. NEPHROL., vol. 22, 2011, pages 635 - 648, XP055556938, DOI: 10.1681/ASN.2009111130
JOURNAL OF THE JAPANESE SOCIETY OF NEPHROLOGY, 2012
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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