Title:
RETENTION OF ENDOTHELIAL CELLS ON VASCULAR GRAFTS
Document Type and Number:
WIPO Patent Application WO2005000107
Kind Code:
A3
Abstract:
An implantable device including a surface containing a plurality of first zones and a plurality of second zones depressed relative to the first zones so as to provide valleys below a plane defined by the first zones, wherein a first zone to second zone width ratio is non-random throughout the device; and a biologically active agent in the valley, wherein the device is adapted to be implanted within an organism such that when said surface is subjected to a flow causing a fluid-induced shear stress, the second zone has a reduced level of the fluid-induced shear stress relative to the first zone in an amount adequate to selectively retain the biologically active agent within the valley.
Inventors:
SHASTRI VENKATRAM PRASAD (US)
GOOCH KEITH J (US)
NICHOL JASON W (US)
GOOCH KEITH J (US)
NICHOL JASON W (US)
Application Number:
PCT/US2004/020441
Publication Date:
December 29, 2005
Filing Date:
June 25, 2004
Export Citation:
Assignee:
PHILADELPHIA CHILDREN HOSPITAL (US)
UNIV PENNSYLVANIA (US)
SHASTRI VENKATRAM PRASAD (US)
GOOCH KEITH J (US)
NICHOL JASON W (US)
UNIV PENNSYLVANIA (US)
SHASTRI VENKATRAM PRASAD (US)
GOOCH KEITH J (US)
NICHOL JASON W (US)
International Classes:
A61F2/02; A61F2/00; A61B; (IPC1-7): A61F2/02
Foreign References:
| US5041091A | 1991-08-20 |
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