Title:
RETINAL GANGLION CELL DEATH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/090705
Kind Code:
A1
Abstract:
The present invention pertains to: a retinal ganglion cell death inhibitor that contains a BMPR signal transduction inhibitor; a protection drug that is for retinal nerves and that contains a BMPR signal transduction inhibitor; and a pharmaceutical composition that uses these and that is for preventing or treating diseases associated with retinal ganglion cell death, such as glaucoma, diabetic retinopathy, and retinal vascular occlusion.
Inventors:
KISHIMOTO YAYOI (JP)
YABUTA CHIHO (JP)
YABUTA CHIHO (JP)
Application Number:
PCT/JP2019/042107
Publication Date:
May 07, 2020
Filing Date:
October 28, 2019
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
International Classes:
A61K45/00; A61K31/4418; A61K31/444; A61K31/519; A61K39/395; A61L27/38; A61P25/00; A61P27/02; A61P27/06; A61P43/00; C12N5/0793
Domestic Patent References:
| WO2017026462A1 | 2017-02-16 | |||
| WO2015103355A1 | 2015-07-09 | |||
| WO2012065059A2 | 2012-05-18 | |||
| WO2018124001A1 | 2018-07-05 | |||
| WO2016011019A1 | 2016-01-21 | |||
| WO2010114860A1 | 2010-10-07 | |||
| WO2015148654A1 | 2015-10-01 | |||
| WO2011116212A2 | 2011-09-22 | |||
| WO2014160203A2 | 2014-10-02 | |||
| WO2016054406A1 | 2016-04-07 |
Foreign References:
| US20150030572A1 | 2015-01-29 | |||
| JP2017537603A | 2017-12-21 | |||
| JP2018204891A | 2018-12-27 | |||
| JP2005518788W |
Other References:
NICOLAS A BELFORTE; JORGE LUIS CUEVA VARGAS; ADRIANA DI POLO: "Metabolic stress in glaucoma engages early activation of the energy biosensor AMPK leading to neuronal dysfunction", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 58, no. 8, 1 June 2017 (2017-06-01), US, pages 2958, XP009528171, ISSN: 0146-0404
YING YING, TAKASHI UETA, SHANSHAN JIANG, HUI LIN, YUANYUAN WANG, DEMETRIOS VAVVAS, RONG WEN, YE-GUANG CHEN, ZHIJUN LUO: "Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK", ONCOTARGET, vol. 8, no. 20, 16 May 2017 (2017-05-16), pages 32794 - 32806, XP055705559, DOI: 10.18632/oncotarget.15825
KHALED HUSSEIN; FANG WANG; AHMED S IBRAHIM; HEBA MOHAMED SALEH; KHALED ELMASRY; NEHAL M EL-SHERBINY; PAUL YU; MOHAMED AL-SAYED AL-: "BMP2 and 4 contribute to retinal endothelial cell barrier dysfunction in diabetic retinopathy: Role of p38 MAPK pathway", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 57, no. 12, 1 September 2016 (2016-09-01), US, pages 5448, XP009528108, ISSN: 0146-0404
YUMI UEKITHOMAS A. REH: "Activation of BMP-Smad1/5/8 Signaling Promotes Survival of Retinal Ganglion Cells after Damage In Vivo", PLOS ONE, vol. 7, June 2012 (2012-06-01), pages e38690
TIAN XY ET AL., J MOL CELL CARDIOL, vol. 52, no. 1, January 2012 (2012-01-01), pages 237 - 44
ACS CHEM NEUROSCI, vol. 3, no. 6, 20 June 2012 (2012-06-20), pages 482 - 91
SELLECK CHEMICALS, BONE, vol. 109, April 2018 (2018-04-01), pages 251 - 258
J MED CHEM., vol. 57, no. 19, 9 October 2014 (2014-10-09), pages 7900 - 15
MED CHEM LETT, vol. 23, no. 11, 1 June 2013 (2013-06-01), pages 3248 - 52
PLOS ONE, vol. 8, no. 4, 30 April 2013 (2013-04-30), pages e62721
B I OORG MED CHEM LETT, vol. 23, no. 11, 1 June 2013 (2013-06-01), pages 3248 - 52
LIU, INVEST OPHTHALMOL VIS SCI, vol. 58, no. 12, 1 October 2017 (2017-10-01), pages 5129 - 5141
XIAO A ET AL., EXP THER MED, vol. 13, no. 6, June 2017 (2017-06-01), pages 3360 - 3368
KAPUPARA K ET AL., CELL DEATH DIS, vol. 8, 16 November 2017 (2017-11-16), pages 11
GUY J ET AL., INVEST OPHTHALMOL VIS SCI, vol. 55, no. 2, 10 February 2014 (2014-02-10), pages 841 - 8
SARZI E ET AL., SCI REP, vol. 8, no. 1, 6 February 2018 (2018-02-06), pages 2468
KHAN RS, INVEST OPHTHALMOL VIS SCI, vol. 55, no. 9, 19 August 2014 (2014-08-19), pages 5744 - 51
W M GRANTD S WALTON, TRANS AM OPHTHALMOL SOC, vol. 72, 1974, pages 207 - 228
INVEST OPHTHALMOL VIS SCI, vol. 47, no. 4, April 2006 (2006-04-01), pages 1477 - 85
J NEUROCHEM, vol. 114, no. 2, July 2010 (2010-07-01), pages 488 - 98
J OPHTHALMOL, 2017, pages 7598140
See also references of EP 3875117A4
YING YING, TAKASHI UETA, SHANSHAN JIANG, HUI LIN, YUANYUAN WANG, DEMETRIOS VAVVAS, RONG WEN, YE-GUANG CHEN, ZHIJUN LUO: "Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK", ONCOTARGET, vol. 8, no. 20, 16 May 2017 (2017-05-16), pages 32794 - 32806, XP055705559, DOI: 10.18632/oncotarget.15825
KHALED HUSSEIN; FANG WANG; AHMED S IBRAHIM; HEBA MOHAMED SALEH; KHALED ELMASRY; NEHAL M EL-SHERBINY; PAUL YU; MOHAMED AL-SAYED AL-: "BMP2 and 4 contribute to retinal endothelial cell barrier dysfunction in diabetic retinopathy: Role of p38 MAPK pathway", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 57, no. 12, 1 September 2016 (2016-09-01), US, pages 5448, XP009528108, ISSN: 0146-0404
YUMI UEKITHOMAS A. REH: "Activation of BMP-Smad1/5/8 Signaling Promotes Survival of Retinal Ganglion Cells after Damage In Vivo", PLOS ONE, vol. 7, June 2012 (2012-06-01), pages e38690
TIAN XY ET AL., J MOL CELL CARDIOL, vol. 52, no. 1, January 2012 (2012-01-01), pages 237 - 44
ACS CHEM NEUROSCI, vol. 3, no. 6, 20 June 2012 (2012-06-20), pages 482 - 91
SELLECK CHEMICALS, BONE, vol. 109, April 2018 (2018-04-01), pages 251 - 258
J MED CHEM., vol. 57, no. 19, 9 October 2014 (2014-10-09), pages 7900 - 15
MED CHEM LETT, vol. 23, no. 11, 1 June 2013 (2013-06-01), pages 3248 - 52
PLOS ONE, vol. 8, no. 4, 30 April 2013 (2013-04-30), pages e62721
B I OORG MED CHEM LETT, vol. 23, no. 11, 1 June 2013 (2013-06-01), pages 3248 - 52
LIU, INVEST OPHTHALMOL VIS SCI, vol. 58, no. 12, 1 October 2017 (2017-10-01), pages 5129 - 5141
XIAO A ET AL., EXP THER MED, vol. 13, no. 6, June 2017 (2017-06-01), pages 3360 - 3368
KAPUPARA K ET AL., CELL DEATH DIS, vol. 8, 16 November 2017 (2017-11-16), pages 11
GUY J ET AL., INVEST OPHTHALMOL VIS SCI, vol. 55, no. 2, 10 February 2014 (2014-02-10), pages 841 - 8
SARZI E ET AL., SCI REP, vol. 8, no. 1, 6 February 2018 (2018-02-06), pages 2468
KHAN RS, INVEST OPHTHALMOL VIS SCI, vol. 55, no. 9, 19 August 2014 (2014-08-19), pages 5744 - 51
W M GRANTD S WALTON, TRANS AM OPHTHALMOL SOC, vol. 72, 1974, pages 207 - 228
INVEST OPHTHALMOL VIS SCI, vol. 47, no. 4, April 2006 (2006-04-01), pages 1477 - 85
J NEUROCHEM, vol. 114, no. 2, July 2010 (2010-07-01), pages 488 - 98
J OPHTHALMOL, 2017, pages 7598140
See also references of EP 3875117A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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