Title:
RGD DIMER COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/099245
Kind Code:
A1
Abstract:
An RGD dimer compound, and a preparation method therefor and a use thereof, relating to the field of nuclear medicine and molecular imaging. The structure of the RGD dimer compound is represented by formula (I) or formula (I-1). Provided are a radionuclide-labeled compound taking the RGD dimer compound represented by formula (I-1) as a ligand, a pharmaceutical composition comprising or composed of the RGD dimer compound, and a kit comprising or composed of the RGD dimer compound or the pharmaceutical composition. Provided is a use of the RGD dimer compound or the pharmaceutical composition in diagnosis or treatment of diseases characterized by over-expression of integrin αvβ3. The RGD dimer compound and the radionuclide-labeled compound have higher tumor uptake and longer retention time, and are expected to be applied to the diagnosis or treatment of diseases characterized by over-expression of the integrin αvβ3.
Inventors:
CHEN XIAOYUAN (CN)
XU PENGFEI (CN)
WU XIAOMING (CN)
GUO ZHIDE (CN)
YANG QINGBAO (CN)
WEN XUEJUN (CN)
XU PENGFEI (CN)
WU XIAOMING (CN)
GUO ZHIDE (CN)
YANG QINGBAO (CN)
WEN XUEJUN (CN)
Application Number:
PCT/CN2023/129842
Publication Date:
May 16, 2024
Filing Date:
November 06, 2023
Export Citation:
Assignee:
YANTAI LANNACHENG BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K7/64; A61K51/08; A61P35/00; A61K101/02
Foreign References:
| CN115433261A | 2022-12-06 | |||
| CN102911256A | 2013-02-06 | |||
| CN114748471A | 2022-07-15 | |||
| CN109153641A | 2019-01-04 | |||
| CN110227169A | 2019-09-13 | |||
| CN115286697A | 2022-11-04 |
Attorney, Agent or Firm:
BEIJING ZHAOJUN UNION INTELLECTUAL PROPERTY LAW FIRM (CN)
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