Title:
RIBAVIRIN ANALOG AND USE THEREOF AS EMBEDDING GROUP
Document Type and Number:
WIPO Patent Application WO/2023/155909
Kind Code:
A1
Abstract:
Disclosed are a ribavirin analog and use thereof as an embedding group in RNAi, and particularly disclosed is a compound as shown in formula (Z).
More Like This:
| JP2008523159 | Reduction of hair growth by sulbibin inhibitors |
| JP2023139014 | METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA |
| WO/2018/098587 | CRISPR-BASED TREATMENT OF FRIEDREICH ATAXIA |
Inventors:
LU JIANYU (CN)
AN KE (CN)
HU YANBIN (CN)
JIANG WEN (CN)
HU LIHONG (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
AN KE (CN)
HU YANBIN (CN)
JIANG WEN (CN)
HU LIHONG (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2023/077236
Publication Date:
August 24, 2023
Filing Date:
February 20, 2023
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
A61K31/713; C07H19/056; C12N15/113
Domestic Patent References:
| WO2021110148A1 | 2021-06-10 | |||
| WO2021249352A1 | 2021-12-16 | |||
| WO2019222166A1 | 2019-11-21 | |||
| WO2004084796A2 | 2004-10-07 | |||
| WO2015179724A1 | 2015-11-26 | |||
| WO2018195165A1 | 2018-10-25 |
Other References:
JEFFREY OLEARCZYK, SHENG GAO, MARIANNE EYBYE, SATYASRI YENDLURI, LORI ANDREWS, STEVEN BARTZ, DORIS CULLY, MARIJA TADIN-STRAPPS: "Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension", HYPERTENSION RESEARCH, THE SOCIETY, vol. 37, no. 5, 1 May 2014 (2014-05-01), pages 405 - 412, XP055206991, ISSN: 09169636, DOI: 10.1038/hr.2013.155
L DUDYEZ , D SHUGAR , E DE CLERCQ , J DESCAMPS : "Synthesis and Determination of Antiviral Activity of the 2’(3’)-O-Methyl Derivatives of Ribavirin(1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 10, 31 December 1977 (1977-12-31), pages 1354 - 1356, XP055818478
DRABIKOWSKA, A. K. ET AL.: "Studies on the mechanism of antiviral action of 1-(.beta.-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (ribavirin)", J. MED. CHEM., vol. 22, no. 6, 1 June 1979 (1979-06-01), XP002170841, DOI: 10.1021/jm00192a009
SCHLEGEL, M. K. ET AL.: "Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA", J. AM. CHEM. SOC., vol. 139, no. 25, 1 June 2017 (2017-06-01), XP055602525, DOI: 10.1021/jacs.7b02694
L DUDYEZ , D SHUGAR , E DE CLERCQ , J DESCAMPS : "Synthesis and Determination of Antiviral Activity of the 2’(3’)-O-Methyl Derivatives of Ribavirin(1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 10, 31 December 1977 (1977-12-31), pages 1354 - 1356, XP055818478
DRABIKOWSKA, A. K. ET AL.: "Studies on the mechanism of antiviral action of 1-(.beta.-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide (ribavirin)", J. MED. CHEM., vol. 22, no. 6, 1 June 1979 (1979-06-01), XP002170841, DOI: 10.1021/jm00192a009
SCHLEGEL, M. K. ET AL.: "Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA", J. AM. CHEM. SOC., vol. 139, no. 25, 1 June 2017 (2017-06-01), XP055602525, DOI: 10.1021/jacs.7b02694
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF: